Details of Drug

Drug General Information (ID: D0018)
Drug Name	Acitretin
Drug Type	Small molecule
Drug Synonymous	Acitretina; Acitretine; Acitretinum; Etretin; Isoacitretin; Isoetretin; Neotigason; Soriatane; TMMP; Acitretina [Spanish]; Acitretine [French]; Acitretinum [Latin]; Retinoid etretin; U0279; Ro 10-1670; Ro 13-7652; Soriatane (TN); Soriatane, Acitretin; Acitretin (USAN/INN); Acitretin [USAN:INN:BAN]; All-trans-Acitretin; Ro 10-1670/000; Ro-10-1670; Ro-13-7652; Ro-10-1670/000; All-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid; (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 13-cis-Acitretin; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid Click to Show/Hide
Disease Class	EA90: Psoriasis
Therapeutic Class	Keratolytic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C21H26O3
InChI	1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
InChIKey	IHUNBGSDBOWDMA-AQFIFDHZSA-N
Canonical SMILES	CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
External Link
	Pubchem ID	5284513
	CAS Number	55079-83-9
	CHEBI ID	50173
	TTD ID	D05QDC
	VARIDT ID	DR00827

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions BM077 Increased risk of pseudotumor cerebri BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Acitretin
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[26], [27], [28]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[29]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[26], [7], [22], [30], [19], [31], [32]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[33]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[34]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[26], [27], [28]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[37], [38], [39], [7], [22], [40], [41], [42], [43], [44], [45], [46], [47]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[48]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[49]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[37], [38], [39], [7], [22], [40], [41], [42], [43], [44], [45], [46], [47]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[22], [50]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[51]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[52], [53]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[54]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[58]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[59], [60], [61], [62]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[7], [22], [65], [66], [67]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[22], [68]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[37], [38], [39], [7], [22], [40], [41], [42], [43], [44], [45], [46], [47]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[7], [22], [70]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[59], [60], [61], [62]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[37], [38], [39], [7], [22], [40], [41], [42], [43], [44], [45], [46], [47]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[71], [72]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[7], [22], [36]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[7], [55], [1], [56], [57]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[7], [22], [36]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[63], [22], [64]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[22], [55], [1], [69]
	Increased risk of pseudotumor cerebri					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0441		Demeclocycline	C21H21ClN2O8	54680690	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0589		Eravacycline	C27H31FN4O8	54726192	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0863		Isotretinoin	C20H28O2	5282379	Major		Inter Info	[22], [14], [24], [7], [19]
D1070		Minocycline	C23H27N3O7	54675783	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1175		Omadacycline	C29H40N4O7	54697325	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1209		Oxytetracycline	C22H24N2O9	54675779	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1445		Sarecycline	C24H29N3O8	54681908	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1564		Tetracycline	C22H24N2O8	54675776	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1626		Tretinoin	C20H28O2	444795	Major		Inter Info	[22], [14], [24], [7], [19]
D0530		Doxycycline	C22H24N2O8	54671203	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1702		Vitamin A	C20H30O	445354	Major		Inter Info	[22], [14], [24], [7], [19]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0617		Ethanol	C2H6O	702	Major		Inter Info	[22], [19]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[22], [35]

References
1	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2	Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
3	Gardner K, Cox T, Digre KB "Idiopathic intracranial hypertension associated with tetracycline use in fraternal twins: case reports and review." Neurology 45 (1995): 6-10. [PMID: 7824136]
4	Chan AY, Liu DT, Friedman DI, Gordon LK, Egan RA "Doxycycline and intracranial hypertension." Neurology 64 (2005): 765-6. [PMID: 15728321]
5	Walters BN, Gubbay SS "Tetracycline and benign intracranial hypertension: report of five cases." Br Med J 282 (1981): 19-20. [PMID: 6449976]
6	Donnet A, Dufour H, Graziani N, Grisoli F "Minocycline and benign intracranial hypertension." Biomed Pharmacother 46 (1992): 171-2. [PMID: 1421048]
7	Cerner Multum, Inc. "Australian Product Information.".
8	Yokokura M, Hatake K, Komatsu N, Kajitani H, Miura Y "Toxicity of tretinoin in acute promyelocytic leukaemia." Lancet 343 (1994): 361-2. [PMID: 7905175]
9	Product Information. Achromycin (tetracycline). Lederle Laboratories, Wayne, NJ.
10	Chiu AM, Chuenkongkaew WL, Cornblath WT, Trobe JD, Digre KB, Dotan SA, Musson KH, Eggenberger ER "Minocycline treatment and pseudotumor cerebri syndrome." Am J Ophthalmol 126 (1998): 116-21. [PMID: 9683157]
11	Lewis PA, Kearney PJ "Pseudotumor cerebri induced by minocycline treatment for acne vulgaris." Acta Derm Venereol 77 (1997): 83. [PMID: 9059695]
12	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
13	Lee AG "Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne." Cutis 55 (1995): 165-8. [PMID: 7634848]
14	Product Information. Accutane (isotretinoin). Roche Laboratories, Nutley, NJ.
15	Tabibian JH, Gutierrez MA "Doxycycline-induced pseudotumor cerebri." South Med J 102 (2009): 310-1. [PMID: 19204639]
16	Cuddihy J "Case report of benign intercranial hypertension secondary to tetracycline." Ir Med J 87 (1994): 90. [PMID: 8056550]
17	Minutello JS, Dimayuga RG, Carter J "Pseudotumor cerebri, a rare adverse reaction to tetracycline therapy." J Periodontol 59 (1988): 848-51. [PMID: 3225732]
18	Roytman M, Frumkin A, Bohn TG "Pseudotumor cerebri caused by isotretinoin." Cutis 42 (1988): 399-400. [PMID: 2973971]
19	Product Information. Soriatane (acitretin). Roche Laboratories, Nutley, NJ.
20	Delaney RA, Narayanaswamy TR "Pseudo-tumor cerebri and acne." Mil Med 155 (1990): 511. [PMID: 2146526]
21	Moskowitz Y, Leibowitz E, Ronen M, Aviel E "Pseudotumor cerebri induced by vitamin A combined with minocycline." Ann Ophthalmol 25 (1993): 306-8. [PMID: 8239326]
22	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
23	Weese-Mayer DE, Yang RJ, Mayer JR, Zaparackas Z "Minocycline and Pseudotumor cerebri: The well-known but well-kept secret." Pediatrics 108 (2001): 519-20. [PMID: 11491116]
24	Product Information. Vesanoid (tretinoin). Roche Laboratories, Nutley, NJ.
25	Schmitt K, Schwarz R, Tulzer G, Krieger O, Zoubek A, Gadner H "Toxicity of tretinoin in acute promyelocytic leukaemia." Lancet 343 (1994): 361. [PMID: 7905174]
26	Canadian Pharmacists Association.
27	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
28	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
29	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
30	Larsen FG, Nielsen-Kudsk F, Jakobsen P, Schroder H, Kragballe K "Interaction of etretinate with methotrexate pharmacokinetics in psoriatic patients." J Clin Pharmacol 30 (1990): 802-7. [PMID: 2277127]
31	Zachariae H "Dangers of methotrexate/etretinate combination therapy." Lancet 1 (1988): 422. [PMID: 2893228]
32	Zachariae H "Methotrexate and etretinate as concurrent therapies in the treatment of psoriasis." Arch Dermatol 120 (1984): 155. [PMID: 6696467]
33	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
34	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
35	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
36	Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
37	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
38	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
39	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
40	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
41	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
42	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
43	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
44	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
45	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
46	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
47	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
48	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
49	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
50	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
51	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
52	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
53	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
54	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
55	Multum Information Services, Inc. Expert Review Panel.
56	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
57	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
58	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
59	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
60	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
61	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
62	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
63	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
64	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
65	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
66	Gilead Sciences, Inc "About Remdesivir.".
67	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
68	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
69	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
70	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
71	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
72	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence