Drug General Information (ID: DDISWLEU3D)
Drug Name			Acitretin		Drug Info		Demeclocycline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Keratolytic Agents				Antibiotics
Structure

Mechanism of Acitretin-Demeclocycline Interaction (Severity Level: Major)
Increased risk of pseudotumor cerebri Click to Show/Hide Mechanism Graph
Drug Name		Acitretin				Demeclocycline
Mechanism		Pseudotumor cerebri				Pseudotumor cerebri
Key Mechanism Factor 1
		Factor Name		Pseudotumor cerebri
		Factor Description		Pseudotumor cerebri syndrome is an elevated intracranial pressure associated with papilledema without an established cause of intracranial hypertension. Symptoms include post-ocular headache, tinnitus, blurred vision, diplopia, transient blindness, nausea and vomiting, dizziness, and swelling of the optic disc in the eye.
Mechanism Description		Increased risk of pseudotumor cerebri by the combination of Acitretin and Demeclocycline

Recommended Action
Management		Coadministration of most retinoids with tetracyclines is considered contraindicated. Patients treated with a retinoid or a tetracycline should be advised to discontinue the medication and notify their physician immediately if they develop early symptoms of pseudotumor cerebri such as headache, nausea, vomiting, visual disturbances, vision loss, and papilledema. Although intracranial hypertension typically resolves after discontinuation of treatment, the possibility for permanent visual loss exists. Therefore, prompt ophthalmologic evaluation should be performed if visual disturbances occur. Since intracranial pressure may remain elevated for weeks after drug cessation, patients should be monitored until they stabilize.

References
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