Drug General Information (ID: DDIZUCJ8AS)
Drug Name			Tacrine		Drug Info		Lacosamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Parasympathomimetics				Analgesics
Structure

Mechanism of Tacrine-Lacosamide Interaction (Severity Level: Moderate)
Increased risk of bradycardia Click to Show/Hide Mechanism Graph
Drug Name		Tacrine				Lacosamide
Mechanism		Bradycardia				Bradycardia
Key Mechanism Factor 1
		Factor Name		Bradycardia
		Factor Description		Bradycardia is a slow heart rate in which the heart beats less than 60 times per minute. If the heart rate is very slow and the heart is not pumping enough oxygen-rich blood to the body, and you may feel dizzy, very tired or weak, and short of breath.
Mechanism Description		Increased risk of bradycardia by the combination of Tacrine and Lacosamide

Recommended Action
Management		Caution is advised if acetylcholinesterase inhibitors are used concomitantly with bradycardic drugs. Patients with underlying structural heart disease, preexisting conduction system abnormalities, ischemic heart disease, or cardiomyopathies may be at increased risk for developing cardiac conduction disturbances and atrioventricular block. Patients should be advised to notify their physician if they experience dizziness, lightheadedness, fainting, or irregular heartbeat.

References
1	Product Information. Cognex (tacrine). Parke-Davis, Morris Plains, NJ.
2	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
3	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCI and digoxin: assessment of pharmacokinetic changes." Br J Clin Pharmacol 46(Suppl 1) (1998): 40-4