Details of Drug

Drug General Information (ID: D1525)
Drug Name	Tacrine
Drug Type	Small molecule
Drug Synonymous	Cognex; Romotal; Tacrina; Tacrinal; Tacrinum; Tenakrin; Tetrahydroaminacrine; Tetrahydroaminoacridine; Tetrahydroaminocrin; Tetrahydroaminocrine; Tha; Tacrine hydrochloride; BBL001044; CS 12602; Cognex (TN); Tacrina [INN-Spanish]; Tacrinal (TN); Tacrine (INN); Tacrine [INN:BAN]; Tacrinum [INN-Latin]; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8); 1,2,3,4-Tetrahydro-9-acridineamine; 1,2,3,4-Tetrahydro-acridin-9-ylamine; 1,2,3,4-Tetrahydroaminoacridine; 1,2,3,4-tetrahydroacridin-9-amine; 5-Amino-6,7,8,9-tetrahydroacridine (European); 9-AMINOTETRAHYDROACRIDINE; 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI); 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate; 9-amino-1,2,3,4-tetrahydroacridine Click to Show/Hide
Disease Class	8A20: Alzheimer disease
Therapeutic Class	Parasympathomimetics
Structure
Structure	3D Structure		2D Structure
Formula	C13H14N2
InChI	1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
InChIKey	YLJREFDVOIBQDA-UHFFFAOYSA-N
Canonical SMILES	C1CCC2=NC3=CC=CC=C3C(=C2C1)N
External Link
	Pubchem ID	1935
	CAS Number	321-64-2
	CHEBI ID	45980
	TTD ID	D0E6YQ
	VARIDT ID	DR00183

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM037 Additive cholinergic effects BM045 Additive neuromuscular blocking effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM055 Increased risk of hepatotoxicity BM069 Increased risk of lowers seizure threshold BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM091 Antagonize the effect of cholinergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tacrine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[27], [39], [51]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[55], [56]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[73]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[76]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[83]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[88]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[89]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[111]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[113]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[36]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[27], [39], [112]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[114]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[49]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[49]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[134]
Pharmacodynamic additive effects
	Additive cholinergic effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[40], [49], [54]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[77], [78]
D0175		Bethanechol	C7H17N2O2+	2370	Moderate		Inter Info	[40], [49], [54]
D0746		Guanidine	CH5N3	3520	Moderate		Inter Info	[40], [49], [54]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[40], [49], [54]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[40], [49], [54]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[40], [49], [54]
	Additive neuromuscular blocking effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[70], [71], [72], [40], [54]
	Increased risk of bradycardia					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[27], [28]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[49], [42], [50]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[49], [42], [50]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[49], [42], [50]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[49], [42], [50]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[49], [42], [50]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[49], [42], [50]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[49], [42], [50]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[49], [42], [50]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[49], [42], [50]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[74], [75]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[49], [42], [50]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[49], [42], [50]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[49], [42], [50]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[81]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[49], [42], [50]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[49], [42], [50]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[39], [86], [87]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[49], [42], [50]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[49], [42], [50]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[49], [42], [50]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[93], [94]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[27], [104]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[49], [42], [50]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[49], [42], [50]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[105]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[49], [42], [50]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[49], [42], [50]
D1088		Moricizine	C22H25N3O4S	34633	Moderate		Inter Info	[49], [42], [50]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[49], [42], [50]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[49], [42], [50]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[49], [42], [50]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[49], [42], [50]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[49], [42], [50]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[49], [42], [50]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[49], [42], [50]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[49], [42], [50]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[49], [42], [50]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[49], [42], [50]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[27], [87]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[49], [42], [50]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[49], [42], [50]
	Increased risk of hepatotoxicity					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[3], [21], [22]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[23]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[24]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[26]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[3], [21], [22]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[52], [27], [53]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[57], [58], [59], [60]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[57], [58], [59], [60]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[61], [52], [62], [27], [39], [63], [64], [65], [66], [67], [68], [53], [69]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[61], [52], [62], [27], [39], [63], [64], [65], [66], [67], [68], [53], [69]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[79]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[80]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[39], [82]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[85]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[90], [91]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[103]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[39], [109]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[110]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[57], [58], [59], [60]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[27], [39], [127], [128], [129]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[39], [131]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[132], [133]
	Increased risk of lowers seizure threshold					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[16], [17], [18], [19], [20]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[16], [17], [18], [19], [20]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[37], [14], [13], [38]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[95], [96], [97], [98], [99], [100], [101], [102]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[106], [107], [108]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[115], [116], [39]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[115], [116], [39]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[115], [116], [39]
	Increased risk of prolong QT interval					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[92]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[39]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
	Increased risk of ventricular arrhythmias					Drug Num: 109
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[25]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0787		Ibutilide	C20H36N2O3S	60753	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0107		Arsenic trioxide	As2O3	14888	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[27], [41], [42]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[27], [41], [42]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[27], [41], [42]
D0514		Dolasetron	C19H20N2O3	3033818	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[27], [41], [42]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[27], [41], [42]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[27], [41], [42]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[27], [41], [42]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Moderate		Inter Info	[27], [41], [42]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[27], [41], [42]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[27], [41], [42]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[27], [41], [42]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[27], [41], [42]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[27], [41], [42]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[27], [41], [42]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[27], [39], [130]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[27], [41], [42]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[3], [27], [39], [40], [41], [42]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0750		Haloperidol	C21H23ClFNO2	3559	Minor		Inter Info	[135], [136], [137]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 76
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[47], [40], [48]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[44], [45], [47]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0124		Atropine (ophthalmic)	C17H23NO3	174174	Moderate		Inter Info	[47], [40], [48]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[47], [40], [48]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[43], [44], [46], [84], [49], [48]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0399		Cyclopentolate (ophthalmic)	C17H25NO3	2905	Moderate		Inter Info	[47], [40], [48]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[44], [45], [47]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[47], [40], [48]
D0760		Homatropine (ophthalmic)	C16H21NO3	5282593	Moderate		Inter Info	[47], [40], [48]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[47], [40], [48]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[44], [45], [47]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[44], [45], [47]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[44], [45], [47]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[47], [40], [48]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1451		Scopolamine (ophthalmic)	C17H21NO4	3000322	Moderate		Inter Info	[47], [40], [48]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[44], [45], [47]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]
D1655		Tropicamide (ophthalmic)	C17H20N2O2	5593	Moderate		Inter Info	[47], [40], [48]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[43], [44], [45], [46], [47], [40], [49], [54], [48]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[43], [44], [45], [46], [47], [48]

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