Drug General Information (ID: DDIEPOV9S4)
Drug Name			Tacrine		Drug Info		Haloperidol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Parasympathomimetics				Antipsychotic Agents
Structure

Mechanism of Tacrine-Haloperidol Interaction (Severity Level: Minor)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Tacrine				Haloperidol
Mechanism		Extrapyramidal effects				Extrapyramidal effects
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Tacrine and Haloperidol

Recommended Action
Management		The patient should be monitored for parkinsonian symptoms if tacrine, haloperidol or a combination is used.

References
1	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
3	McSwain ML, Forman LM "Severe parkinsonian symptom development on combination treatment with tacrine and haloperidol." J Clin Psychopharmacol 15 (1995): 284