Details of Drug

Drug General Information (ID: D0885)
Drug Name	Lacosamide
Drug Type	Small molecule
Drug Synonymous	Erlosamide; Harkoseride; Vimpat; Erlosamide [INN]; Lacosamide [USAN]; ADD 234037; SPM 927; ADD-234037; SPM-927; SPM-929; Erlosamide, Vimpat, Lacosamide; Lacosamide (USAN/INN); (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-acetamido-N-benzyl-3-methoxypropanamide Click to Show/Hide
Disease Class	8A61-8A6Z: Epilepsy/seizure; 8C0Z: Neuropathy
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C13H18N2O3
InChI	1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
InChIKey	VPPJLAIAVCUEMN-GFCCVEGCSA-N
Canonical SMILES	CC(=O)NC(COC)C(=O)NCC1=CC=CC=C1
External Link
	Pubchem ID	219078
	CAS Number	175481-36-4
	CHEBI ID	135939
	TTD ID	D05OFX
	INTEDE ID	DR0911

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM087 Antagonize the effect of antiepileptic agents
Relation Graph

Full list of drugs interacting with Lacosamide
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[4], [5], [13]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[4], [5], [13]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[4], [5], [13]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[4], [5], [13]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[4], [5], [13]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[4], [5], [13]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4], [5], [13]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[4], [5], [13]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[4], [5], [13]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[4], [5], [13]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[4], [5], [13]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[4], [5], [13]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[4], [5], [13]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[4], [5], [13]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[4], [5], [13]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[4], [5], [13]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[4], [5], [13]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[4], [5], [13]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[4], [5], [13]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[4], [5], [13]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[4], [5], [13]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[4], [5], [13]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[4], [5], [13]
	CYP450 enzyme induction					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[5], [13]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[5], [13]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[5], [67], [13]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[5], [13]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[8], [9]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[39], [40], [41], [5], [42]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[43]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[46]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[4], [50]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[54]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[59], [60], [61], [62], [63]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[65], [5], [4]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[66]
	Increased risk of atrioventricular block					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[3]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[13]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[13]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[13]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[13]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[13]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[13]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[13]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[13]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[13]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[13]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[13]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[13]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[13]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[13]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[13]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[13]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[13]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[13]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[13]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[13]
D1088		Moricizine	C22H25N3O4S	34633	Moderate		Inter Info	[13]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[13]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[13]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[13]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[13]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[13]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[13]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[13]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[13]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[13]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[13]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[13]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[13]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[64], [49]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[13]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[13]
	Increased risk of bradycardia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[4], [5], [6]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [7]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[10], [11], [12]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[36], [37], [38]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[36], [37], [38]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[44], [45]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[47]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[5], [48], [49]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[51], [52]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[4], [53]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[55]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[56], [4], [5], [57], [58]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[36], [37], [38]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[36], [37], [38]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[4], [5], [14], [15], [16]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[4], [5], [14], [15], [16]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[17], [18], [19], [20], [21], [22], [23], [24], [5], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]

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