Details of Drug-Drug Interaction
| Drug General Information (ID: DDIXINH5OD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Calcium carbonate | Drug Info | Neratinib | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antacids/Minerals And Electrolytes | Antineoplastics | |||||||
| Structure | |||||||||
| Mechanism of Calcium carbonate-Neratinib Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Calcium carbonate | Neratinib | |||||||
| Mechanism | Gastric alkalinizer | Gastric pH sensitive | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Concomitant use of neratinib with drugs that increase gastric pH should generally be avoided. If acid-suppression therapy is required, short-acting antacids should be considered, with neratinib dosing separated by at least three hours after antacid administration. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA. | ||||||||||||||||||