Details of Drug

Drug General Information (ID: D1124)
Drug Name	Neratinib
Drug Type	Small molecule
Drug Synonymous	Neratinib (ERBB2 inhibitor) Click to Show/Hide
Disease Class	2C60-2C6Y: Breast cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C30H29ClN6O3
InChI	1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChIKey	JWNPDZNEKVCWMY-VQHVLOKHSA-N
Canonical SMILES	CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
External Link
	Pubchem ID	9915743
	CAS Number	698387-09-6
	CHEBI ID	61397
	TTD ID	D0Q9CY
	INTEDE ID	DR1887

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM005 Altered gastric pH BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Neratinib
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[2], [3]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Major		Inter Info	[2], [3]
D0603		Esomeprazole	C17H19N3O3S	9568614	Major		Inter Info	[2], [3]
D0636		Famotidine	C8H15N7O2S3	5702160	Major		Inter Info	[2], [3]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Major		Inter Info	[2], [3]
D1151		Nizatidine	C12H21N5O2S2	3033637	Major		Inter Info	[2], [3]
D1179		Omeprazole	C17H19N3O3S	4594	Major		Inter Info	[2], [3]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Major		Inter Info	[2], [3]
D1373		Rabeprazole	C18H21N3O3S	5029	Major		Inter Info	[2], [3]
D1381		Ranitidine	C13H22N4O3S	3001055	Major		Inter Info	[2], [3]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Major		Inter Info	[2], [3]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[3]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[3]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[3]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[3]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[3]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[3]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[3]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[3]
Affected cellular transport
	Transporter inhibition					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[4], [5], [6]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[7], [8], [9], [10]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[11]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[2], [12]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[13]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[15], [7], [16], [17]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[7], [18], [19]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[7], [20]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[21], [22]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[23]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[24], [25], [26], [27]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[24], [26], [27]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[28], [19]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[24], [25], [26], [27]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[29]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[7], [30]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[31]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[2], [7], [32]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[7], [33]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[35]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[36]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[2], [37]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[38]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[39]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[2], [7], [45]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[46]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[47]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 50
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[1], [2], [3]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[1], [2], [3]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2], [3]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[1], [2], [3]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2], [3]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1], [2], [3]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2], [3]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[1], [2], [3]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1], [2], [3]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1], [2], [3]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2], [3]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2], [3]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2], [3]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2], [3]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[1], [2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1], [2], [3]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[1], [2], [3]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1], [2], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2], [3]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[1], [2], [3]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1], [2], [3]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[1], [2], [3]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[1], [2], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[2], [7], [3], [14]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[1], [2], [3]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1], [2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[34]
	CYP450 enzyme induction					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[2], [3]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[2], [3]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[2], [3]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[2], [3]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[2], [3]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[2], [3]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[2], [3]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[2], [3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[2], [3]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [3]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[2], [3]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[2], [3]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[2], [3]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[2], [3]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[2], [3]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[2], [3]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[2], [3]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[2], [3]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[2], [3]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[2], [3]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[2], [3]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[2], [3]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[40], [41], [42], [43], [44]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[1], [2]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[1], [2]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[1], [2]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[1], [2]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[1], [2]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[1], [2]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[1], [2]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[1], [2]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[1], [2]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[1], [2]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[1], [2]

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