Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIXG74OH2)
  Drug Name Azilsartan medoxomil Drug Info Angiotensin II Drug Info
  Drug Type Small molecule Hormones
  Therapeutic Class Antihypertensive Agents Hormone Modulators
  Structure

 Mechanism of Azilsartan medoxomil-Angiotensin II Interaction (Severity Level: Moderate)
     Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Azilsartan medoxomil Angiotensin II
      Mechanism Antihypertensive agent
Angiotensin II receptor  Antagonist 		Hypertensive effects
Angiotensin II receptor  Agonist
      Key Mechanism Factor 1
Factor Name Angiotensin II receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Azilsartan medoxomil when combined with Angiotensin II 

Recommended Action
      Management Close monitoring of therapeutic response is recommended when angiotensin II is administered to patients treated with angiotensin II receptor antagonists.

References
1 Product Information. Cozaar (losartan). Merck &amp Co, Inc, West Point, PA.
2 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
3 Product Information. Giapreza (angiotensin II). La Jolla Pharmaceutical, San Diego, CA.