Details of Drug

Drug General Information (ID: D0138)
Drug Name	Azilsartan medoxomil
Drug Type	Small molecule
Drug Synonymous	TAK 491 Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C30H24N4O8
InChI	1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)
InChIKey	QJFSABGVXDWMIW-UHFFFAOYSA-N
Canonical SMILES	CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)OCC6=C(OC(=O)O6)C
External Link
	Pubchem ID	135409642
	CAS Number	863031-21-4
	CHEBI ID	68845
	TTD ID	D0A2RA
	INTEDE ID	DR1934

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM032 Decreased renal excretion (Unspecific) BM042 Additive hypotensive effects BM048 Increased risk of angioedema/anaphylactoid reactions BM058 Increased risk of hyperkalemia BM064 Increased risk of hypoglycemia BM072 Increased risk of nephrotoxicity BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Azilsartan medoxomil
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[31], [32], [33]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 148
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[46]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[80]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[81], [82], [83]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[84], [85], [86]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[81], [82], [83]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[87], [88], [89]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[81], [82], [83]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[81], [82], [83]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[81], [82], [83]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[87], [98], [99]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[100], [101], [102]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[103], [104], [105]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[81], [82], [83]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[107], [39], [108]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[107], [39], [108]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[112], [113], [114]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[81], [82], [83]
D1183		Opium	NA	NA	Moderate		Inter Info	[81], [82], [83]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[81], [82], [83]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[81], [82], [83]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[129]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[39], [130], [131]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[81], [82], [83]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[81], [82], [83]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[100], [101], [102]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[100], [101], [102]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[81], [82], [83]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[81], [82], [83]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[81], [82], [83]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[81], [82], [83]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[81], [82], [83]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[81], [82], [83]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[81], [82], [83]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[81], [82], [83]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[81], [82], [83]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[81], [82], [83]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[81], [82], [83]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[81], [82], [83]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[81], [82], [83]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[81], [82], [83]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[81], [82], [83]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[81], [82], [83]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[81], [82], [83]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[81], [82], [83]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[107], [39], [108]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[81], [82], [83]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[107], [138], [139]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[81], [82], [83]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[81], [82], [83]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[81], [82], [83]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[81], [82], [83]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[81], [82], [83]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[81], [82], [83]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[81], [82], [83]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[81], [82], [83]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[39], [130], [131]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[81], [82], [83]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[81], [82], [83]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[88], [146]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[81], [82], [83]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[81], [82], [83]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[107], [39], [147]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[81], [82], [83]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[81], [82], [83]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[81], [82], [83]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[81], [82], [83]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[39], [130], [131]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[81], [82], [83]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[81], [82], [83]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[81], [82], [83]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[39], [224], [225]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[81], [82], [83]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[81], [82], [83]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[226]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[81], [82], [83]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[81], [82], [83]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[81], [82], [83]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[81], [82], [83]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[81], [82], [83]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[81], [82], [83]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[81], [82], [83]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[81], [82], [83]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[81], [82], [83]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[81], [82], [83]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[81], [82], [83]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[227], [228], [225]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[81], [82], [83]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[81], [82], [83]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[81], [82], [83]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[81], [82], [83]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[81], [82], [83]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[81], [82], [83]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[81], [82], [83]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[229]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[81], [82], [83]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[81], [82], [83]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[81], [82], [83]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[81], [82], [83]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[81], [82], [83]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[103], [104], [105]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[81], [82], [83]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[81], [82], [83]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[81], [82], [83]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [88], [125], [126]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[81], [82], [83]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[39], [130], [131]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[81], [82], [83]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[90], [91], [92], [93], [84], [94], [85], [95], [86], [96], [97]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[103], [104], [105]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[81], [82], [83]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[81], [82], [83]
D0711		Garlic	NA	NA	Minor		Inter Info	[233], [234]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[235], [236]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[143], [144], [145]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[39], [230], [231]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[143], [144], [145]
	Increased risk of hyperkalemia					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0058		Amiloride	C6H8ClN7O	16231	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0038		Aliskiren	C30H53N3O6	5493444	Major		Inter Info	[25], [26], [27], [28], [29], [30]
D1086		Monopotassium phosphate	H2KO4P	516951	Major		Inter Info	[4], [23], [16]
D1316		Potassium acetate	C2H3KO2	517044	Major		Inter Info	[16], [14], [2], [23], [6], [24], [15], [20], [34], [21], [4]
D1317		Potassium bicarbonate	CHKO3	516893	Major		Inter Info	[16], [14], [2], [23], [6], [24], [15], [20], [34], [21], [4]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[16], [14], [2], [23], [6], [24], [15], [20], [34], [21], [4]
D1320		Potassium gluconate	C6H11KO7	16760467	Major		Inter Info	[16], [14], [2], [23], [6], [24], [15], [20], [34], [21], [4]
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[16], [14], [2], [23], [6], [24], [15], [20], [34], [21], [4]
D1321		Potassium Iodide	IK	4875	Major		Inter Info	[16], [14], [2], [23], [6], [24], [15], [20], [34], [21], [4]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[6], [35], [36], [37], [29], [38], [28], [18], [39], [27], [40], [41], [42], [43], [44], [45]
D1631		Triamterene	C12H11N7	5546	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1645		Trimethoprim	C14H18N4O3	5578	Major		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [21], [34], [61], [62], [63], [64], [65], [66], [67], [15], [68], [69], [20], [5], [70], [71], [72], [73], [74], [75], [76]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[6], [35], [134], [18], [135], [39], [14], [20], [136], [137]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[140], [141]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[6], [35], [134], [18], [135], [39], [14], [20], [136], [137]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[142], [5]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[20], [39]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[6], [35], [134], [18], [135], [39], [14], [20], [136], [137]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[232]
	Increased risk of hypoglycemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[148], [149], [150]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[148], [149], [150]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[151], [152], [153], [154], [155], [156], [157], [148], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [149], [202], [203], [204], [205], [206], [207], [208], [209], [210], [150], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[151], [152], [153], [154], [155], [156], [157], [148], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [149], [202], [203], [204], [205], [206], [207], [208], [209], [210], [150], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[151], [152], [153], [154], [155], [156], [157], [148], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [149], [202], [203], [204], [205], [206], [207], [208], [209], [210], [150], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[148], [149], [150]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[148], [149], [150]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[148], [149], [150]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[148], [149], [150]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[148], [149], [150]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[148], [149], [150]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[151], [152], [153], [154], [155], [156], [157], [148], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [149], [202], [203], [204], [205], [206], [207], [208], [209], [210], [150], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[148], [149], [150]
	Increased risk of nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[107], [39], [132], [20], [133]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[6], [127], [128]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[6], [127], [128]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[6], [127], [128]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 41
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[77], [78], [79]
D1738		Angiotensin II	C50H71N13O12	172198	Moderate		Inter Info	[31], [6], [106]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[77], [78], [79]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[39], [77]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[109], [110], [111]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[77], [78], [79]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[39], [77]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[77], [78], [79]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[39], [77]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[77], [78], [79]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[39], [77]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[39], [77]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[77], [78], [79]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[77], [78], [79]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[77], [78], [79]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[77], [78], [79]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[39], [77]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[77], [78], [79]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[39], [77]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[77], [78], [79]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[77], [78], [79]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[77], [78], [79]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[77], [78], [79]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[77], [78], [79]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[77], [78], [79]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[77], [78], [79]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[39], [77]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[77], [78], [79]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[77], [78], [79]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[77], [78], [79]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[77], [78], [79]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[77], [78], [79]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[39], [77]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[39], [77]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[77], [78], [79]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[77], [78], [79]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[77], [78], [79]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[77], [78], [79]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[39], [77]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[77], [78], [79]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[39], [77]

References
1	Product Information. Midamor (amiloride). Merck & Co, Inc, West Point, PA.
2	Jarman PR, Kehely AM, Mather HM "Hyperkalaemia in diabetes: prevalence and associations." Postgrad Med J 71 (1995): 551-2. [PMID: 7479468]
3	McNay JL, Oran E "Possible predisposition of diabetic patients to hyperkalemia following administration of potassium-retaining diuretic, amiloride (MK 870)." Metabolism 19 (1970): 58-70. [PMID: 5410663]
4	Obialo CI, Ofili EO, Mirza T "Hyperkalemia in congestive heart failure patients aged 63 to 85 years with subclinical renal disease." Am J Cardiol 90 (2002): 663-5. [PMID: 12231103]
5	Marcy TR, Ripley TL "Aldosterone antagonists in the treatment of heart failure." Am J Health Syst Pharm 63 (2006): 49-58. [PMID: 16373465]
6	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
7	Tamirisa KP, Aaronson KD, Koelling TM "Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure." Am Heart J 148 (2004): 971-8. [PMID: 15632880]
8	Fujii H, Nakahama H, Yoshihara F, Nakamura S, Inenaga T, Kawano Y "Life-threatening hyperkalemia during a combined therapy with the angiotensin receptor blocker candesartan and spironolactone." Kobe J Med Sci 51 (2005): 1-6. [PMID: 16199929]
9	Wrenger E, Muller R, Moesenthin M, Welte T, Frolich JC, Neumann KH "Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases." BMJ 327 (2003): 147-9. [PMID: 12869459]
10	McMurray JJ, O'Meara E "Treatment of heart failure with spironolactone--trial and tribulations." N Engl J Med 351 (2004): 526-8. [PMID: 15295043]
11	Spironolactone + ace inhibitor or sartan: risk of hyperkalaemia. Prescrire Int 13 (2004): 58. [PMID: 15148978]
12	Canadian Pharmacists Association.
13	Svensson M, Gustafsson F, Galatius S, Hildebrandt PR, Atar D "Hyperkalaemia and impaired renal function in patients taking spironolactone for congestive heart failure: retrospective study." BMJ 327 (2003): 1141-2. [PMID: 14615339]
14	Product Information. Cozaar (losartan). Merck & Co, Inc, West Point, PA.
15	Perazella MA, Mahnensmith RL "Hyperkalemia in the elderly: drugs exacerbate impaired potassium homeostasis." J Gen Intern Med 12 (1997): 646-56. [PMID: 9346463]
16	Walmsley RN, White GH, Cain M, McCarthy PJ, Booth J "Hyperkalemia in the elderly." Clin Chem 30 (1984): 1409-12. [PMID: 6744599]
17	Bozkurt B, Agoston I, Knowlton AA "Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines." J Am Coll Cardiol 41 (2003): 211-4. [PMID: 12535810]
18	Product Information. Atacand (candesartan). Astra Pharmaceuticals, Wayne, PA.
19	Desai AS, Swedberg K, McMurray JJ, et al. "Incidence and predictors of hyperkalemia in patients with heart failure: an analysis of the CHARM Program." J Am Coll Cardiol 50 (2007): 1959-66. [PMID: 17996561]
20	Perazella MA "Drug-induced hyperkalemia: old culprits and new offenders." Am J Med 109 (2000): 307-14. [PMID: 10996582]
21	Lawson DH, O'Connor PC, Jick H "Drug attributed alterations in potassium handling in congestive cardiac failure." Eur J Clin Pharmacol 23 (1982): 21-5. [PMID: 7128669]
22	Masoudi FA, Gross CP, Wang Y, et al. "Adoption of spironolactone therapy for older patients with heart failure and left ventricular systolic dysfunction in the United States, 1998-2001." Circulation 112 (2005): 39-47. [PMID: 15983243]
23	Jarman PR, Mather HM "Diabetes may be independent risk factor for hyperkalaemia." BMJ 327 (2003): 812. [PMID: 14525902]
24	Large DM, Carr PH, Laing I, Davies M "Hyperkalaemia in diabetes mellitus--potential hazards of coexisting hyporeninaemic hypoaldosteronism." Postgrad Med J 60 (1984): 370-3. [PMID: 6377287]
25	Health Canada "Potential risks of cardiovascular and renal adverse events in patients with type 2 diabetes treated with aliskiren (RASILEZ) or aliskiren/hydrochlorothiazide (RASILEZ HCT)." .
26	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
27	EMA. European Medicines Agency "PRAC recommends against combined use of medicines affecting the renin-angiotensin (RAS) system: recommendation will now be considered by CHMP for final opinion." .
28	MHRA. Medicines and Healthcare Regulatory Agency "Combination use of medicines from different classes of renin-angiotensin system blocking agents: risk of hyperkalaemia, hypotension, and impaired renal function--new warnings.".
29	National Kidney Foundation "KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 update." Am J Kidney Dis 60 (2012): 850-86. [PMID: 23067652]
30	Novartis International AG "Novartis announces termination of ALTITUDE study with Rasilez Tekturna in high-risk patients with diabetes and renal impairment.".
31	Product Information. Cozaar (losartan). Merck &amp Co, Inc, West Point, PA.
32	Spinewine A, Schoevaerdts D, Mwenge GB, Swine C, Dive A "Drug-induced lithium intoxication: a case report." J Am Geriatr Soc 53 (2005): 360-1.[PMID: 15673374]
33	Blanche P, Raynaud E, Kerob D, Galezowski N "Lithium intoxication in an elderly patient after combined treatment with losartan." Eur J Clin Pharmacol 52 (1997): 501.[PMID: 9342587]
34	Lawson DH "Adverse reactions to potassium chloride." Q J Med 43 (1974): 433-40. [PMID: 4424028]
35	Product Information. Micardis (telmisartan). Boehringer-Ingelheim, Ridgefield, CT.
36	ONTARGET Investigators, Yusuf S, Teo KK, et al "Telmisartan, ramipril, or both in patients at high risk for vascular events." N Engl J Med 358 (2008): 1547-59. [PMID: 18700309]
37	Rossing K, Jacobsen P, Pietraszek L, Parving HH "Renoprotective effects of adding angiotensin II receptor blocker to maximal recommended doses of ACE inhibitor in diabetic nephropathy: a randomized double-blind crossover trial." Diabetes Care 26 (2003): 2268-74. [PMID: 12882847]
38	Jacobsen P, Andersen S, Rossing K, Jensen BR, Parving HH "Dual blockade of the renin-angiotensin system versus maximal recommended dose of ACE inhibition in diabetic nephropathy." Kidney Int 63 (2003): 1874-80. [PMID: 12675866]
39	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
40	Laverman GD, Navis G, Henning RH, De Jong PE, De Zeeuw D "Dual renin-angiotensin system blockade at optimal doses for proteinuria." Kidney Int 62 (2002): 1020-5. [PMID: 12164886]
41	Pfeffer MA, McMurray JJ, Velazquez EJ, et al. "Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both." N Engl J Med 349 (2003): 1893-1906. [PMID: 14610160]
42	McMurray JJ, Ostergren J, Swedberg K, et al. "Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial." Lancet 362 (2003): 767-71. [PMID: 13678869]
43	Jacobsen P, Andersen S, Jensen BR, Parving HH "Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathy." J Am Soc Nephrol 14 (2003): 992-9. [PMID: 12660333]
44	Guthrie RM "Review of ONTARGET: treating patients at high risk for vascular events with telmisartan, ramipril, or both. Commentary." Postgrad Med 121 (2009): 202-4. [PMID: 19332981]
45	Mann JF, Schmieder RE, McQueen M, et al. "Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial." Lancet 372 (2008): 547-53. [PMID: 18707986]
46	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
47	Canaday DH, Johnson JR "Hyperkalemia in elderly patients receiving standard doses of trimethoprim-sulfamethoxazole." Ann Intern Med 120 (1994): 438. [PMID: 8304666]
48	Witt JM, Koo JM, Danielson BD "Effect of standard-dose trimethoprim/sulfamethoxazole on the serum potassium concentration in elderly men." Ann Pharmacother 30 (1996): 347-50. [PMID: 8729886]
49	Alappan R, Perazella MA, Buller GK "Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole." Ann Intern Med 124 (1996): 316-20. [PMID: 8554227]
50	Perlmutter EP, Sweeney D, Herskovits G, Kleiner M "Case report: severe hyperkalemia in a geriatric patient receiving standard doses of trimethoprim-sulfamethoxazole." Am J Med Sci 311 (1996): 84-5. [PMID: 8615380]
51	Perazella MA, Mahnensmith RL "Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose." Clin Nephrol 46 (1996): 187-92. [PMID: 8879854]
52	Marinella MA "Trimethoprim-sulfamethoxazole associated with hyperkalemia." West J Med 167 (1997): 356-8. [PMID: 9392994]
53	Hsu I, Wordell CJ "Hyperkalemia and high-dose trimethoprim/sulfamethoxazole." Ann Pharmacother 29 (1995): 427-9. [PMID: 7633023]
54	Antoniou T, Gomes T, Juurlink DN, Loutfy MR, Glazier RH, Mamdani MM "Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study." Arch Intern Med 170 (2010): 1045-9. [PMID: 20585070]
55	Velazquez H, Perazella MA, Wright FS, Ellison DH "Renal mechanism of trimethoprim-induced hyperkalemia." Ann Intern Med 119 (1993): 296-301. [PMID: 8328738]
56	Marinella MA "Reversible hyperkalemia associated with trimethoprim-sulfamethoxazole." Am J Med Sci 310 (1995): 115-7. [PMID: 7668307]
57	Choi MJ, Fernandez PC, Patnaik A, Coupaye-Gerard B, D'Andrea D, Szerlip H, Kleyman TR "Brief report: trimethoprim-induced hyperkalemia in a patient with AIDS." N Engl J Med 328 (1993): 703-6. [PMID: 8433730]
58	Lin SH, Kuo AA, Yu FC, Lin YF "Reversible voltage-dependent distal renal tubular acidosis in a patient receiving standaard doses of trimethoprim-sulphamethoxazole." Nephrol Dial Transplant 12 (1997): 1031-33. [PMID: 9175064]
59	Thomas RJ "Severe hyperkalemia with trimethoprim-quinapril." Ann Pharmacother 30 (1996): 413-4. [PMID: 8729901]
60	Marinella MA "Severe hyperkalemia associated with trimethoprim-sulfamethoxazole and spironolactone." Infect Dis Clin Pract 6 (1997): 256-8.
61	Perazella MA, Alappan R, Buller GK "Hyperkalemia and trimethoprim-sulfamethoxazole." Ann Intern Med 125 (1996): 1015. [PMID: 8929019]
62	Noto H, Kaneko Y, Takano T, Kurokawa K "Severe hyponatremia and hyperkalemia induced by trimethoprim-sulfamethoxazole in patients with Pneumocystis carinii pneumonia." Intern Med 34 (1995): 96-9. [PMID: 7727887]
63	Greenberg S, Reiser IW, Chou SY, Porush JG. Trimethoprim-sulfamethoxazole induces reversible hyperkalemia.?Ann Intern Med. 1993;119(4):291-295. [PMID: 8328737]
64	Mihm LB, Rathbun RC, Resmantargoff BH "Hyperkalemia associated with high-dose trimethoprim-sulfamethoxazole in a patient with the acquired immunodeficiency syndrome." Pharmacotherapy 15 (1995): 793-7. [PMID: 8602391]
65	Product Information. Bactrim (trimethoprim-sulfamethoxazole). Roche Laboratories, Nutley, NJ.
66	Mori H, Kuroda Y, Imamura S, et al "Hyponatremia and/or hyperkalemia in patients treated with the standard dose of trimethoprim-sulfamethoxazole." Intern Med 42 (2003): 665-9. [PMID: 12924488]
67	Lee SW, Park SW, Kang JM "Intraoperative hyperkalemia induced by administration of trimethoprim-sulfamethoxazole in a patient receiving angiotensin receptor blockers." J Clin Anesth 26 (2014): 427-8. [PMID: 25128254]
68	Martin J, Mourton S, Nicholls G "Severe hyperkalaemia with prescription of potassium-retaining agents in an elderly patient." N Z Med J 116 (2003): U542. [PMID: 14513088]
69	Modest GA, Price B, Mascoli N "Hyperkalemia in elderly patients receiving standard doses of trimethoprim-sulfamethoxazole." Ann Intern Med 120 (1994): 437. [PMID: 8304664]
70	Koc M, Bihorac A, Ozener CI, Kantarci G, Akoglu E "Severe hyperkalemia in two renal transplant recipients treated with standard dose of trimethoprim-sulfamethoxazole." Am J Kidney Dis 36 (2000): u59-64. [PMID: 10977811]
71	Bugge JF "Severe hyperkalaemia induced by trimethoprim in combination with an angiotensin-converting enzyme inhibitor in a patient with transplanted lungs." J Intern Med 240 (1996): 249-51. [PMID: 8918517]
72	Smith GW, Cohen SB "Hyperkalaemia and non-oliguric renal failure associated with trimethoprim." Br Med J 308 (1994): 454. [PMID: 8124180]
73	Eiam-Ong S, Kurtzman NA, Sabatini S "Studies on the mechanism of trimethoprim-induced hyperkalemia." Kidney Int 49 (1996): 1372-8. [PMID: 8731102]
74	Fouche R, Bernardin G, Roger PM, Corcelle P, Simler JM, Mattei M "Hyperkaliemia in a patient given high-dose trimethoprim-sulfamethoxazole." Presse Med 25 (1996): 2044. [PMID: 9082385]
75	Pennypacker LC, Mintzer J, Pitner J "Hyperkalemia in elderly patients receiving standard doses of trimethoprim-sulfamethoxazole." Ann Intern Med 120 (1994): 437. [PMID: 8304665]
76	Greenberg S, Reiser IW, Chou SY "Hyperkalemia with high-dose trimethoprim-sulfamethoxazole therapy." Am J Kidney Dis 22 (1993): 603-6. [PMID: 8213804]
77	Multum Information Services, Inc. Expert Review Panel.
78	Product Information. Toradol (ketorolac). Roche Laboratories, Nutley, NJ.
79	Radack KL, Deck CC, Bloomfield SS "Ibuprofen interferes with the efficacy of antihypertensive drugs: a randomized, double-blind, placebo-controlled trial of ibuprofen compared with acetaminophen." Ann Intern Med 107 (1987): 628-35. [PMID: 2889416]
80	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
81	Ellison JM, Milofsky JE, Ely E "Fluoxetine-induced bradycardia and syncope in two patients." J Clin Psychiatry 51 (1990): 385-6. [PMID: 2211552]
82	Feder R "Bradycardia and syncope induced by fluoxetine." J Clin Psychiatry 52 (1991): 139. [PMID: 2005082]
83	Sternbach H "Fluoxetine-associated potentiation of calcium-channel blockers." J Clin Psychopharmacol 11 (1991): 390-1. [PMID: 1770159]
84	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
85	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
86	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
87	Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
88	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
89	Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
90	Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
91	Fruncillo R, Gibbons W, Vlasses P, Ferguson R "Severe hypotension associated with concurrent clonidine and antipsychotic medication." Am J Psychiatry 142 (1985): 274. [PMID: 2857531]
92	Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9. [PMID: 7663034]
93	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
94	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
95	Product Information. Risperdal (risperidone). Janssen Pharmaceutica, Titusville, NJ.
96	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
97	White WB "Hypotension with postural syncope secondary to the combination of chlorpromazine and captopril." Arch Intern Med 146 (1986): 1833-4. [PMID: 3530167]
98	Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
99	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
100	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
101	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
102	Walters TR "Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: a review of safety, efficacy, dose response, and dosing studies." Surv Ophthalmol 41 ( Suppl (1996): s19-26
103	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
104	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
105	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
106	Product Information. Giapreza (angiotensin II). La Jolla Pharmaceutical, San Diego, CA.
107	Cerner Multum, Inc. "Australian Product Information.".
108	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
109	Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age." Lancet 2 (1987): 821-4. [PMID: 2889032]
110	Cumming AM "Metabolic effects of licorice." Br Med J 1 (1977): 906
111	Epstein MT, Espiner EA, Donald RA, Hughes H "Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects." Br Med J 1 (1977): 488-90
112	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
113	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
114	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
115	Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
116	De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
117	Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
118	Golwyn DH, Sevlie CP "Monoamine oxidase inhibitor hypertensive crisis headache and orthostatic hypotension." J Clin Psychopharmacol 13 (1993): 77-8. [PMID: 8486823]
119	Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
120	Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
121	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
122	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
123	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
124	Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
125	Reggev A, Vollhardt BR "Bradycardia induced by an interaction between phenelzine and beta blockers." Psychosomatics 30 (1992): 106-8. [PMID: 2913594]
126	Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
127	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
128	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
129	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
130	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
131	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
132	Murray BM, Venuto RC, Kohli R, Cunningham EE "Enalapril-associated acute renal failure in renal transplants: possible role of cyclosporine." Am J Kidney Dis 16 (1990): 66-9. [PMID: 2368707]
133	Product Information. Neoral Soft Gelatin Capsules (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
134	Product Information. Avapro (irbesartan). Bristol-Myers Squibb, Princeton, NJ.
135	Product Information. Teveten (eprosartan). SmithKline Beecham, Philadelphia, PA.
136	Product Information. Edarbi (azilsartan). Takeda Pharmaceuticals America, Lincolnshire, IL.
137	Product Information. Benicar (olmesartan). Sankyo Parke Davis, Parsippany, NJ.
138	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
139	Product Information. Precedex (dexmedetomidine) Abbott Pharmaceutical, Abbott Park, IL.
140	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
141	Ponce SP, Jennings AE, Madias NE, Harrington JT "Drug-induced hyperkalemia." Medicine (Baltimore) 64 (1985): 357-70. [PMID: 2865667]
142	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
143	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
144	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
145	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
146	Product Information. Corlopam (fenoldopam). Neurex, Menlo Park, CA.
147	Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
148	Asplund K, Wiholm BE, Lithner F "Glibenclamide-associated hypoglycaemia: a report on 57 cases." Diabetologia 24 (1983): 412-7. [PMID: 6411511]
149	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
150	Semel JD, Wortham E, Karl DM "Fasting hypoglycemia associated with disopyramide." Am Heart J 106 (1983): 1160-1. [PMID: 6356848]
151	Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Ceron D "Possible interaction between glicazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia." Br J Clin Pharmacol 52 (2001): 456-7. [PMID: 11678792]
152	Ahmad S "Drug interaction induces hypoglycemia." J Fam Pract 40 (1995): 540-1. [PMID: 7775905]
153	Ahmad S "Gemfibrozil: interaction with glyburide." South Med J 84 (1991): 102. [PMID: 1898783]
154	Aleyassine H, Gardiner RJ "Dual action of antidepressant drugs (MAO inhibitors) on insulin release." Endocrinology 96 (1975): 702-10. [PMID: 1090438]
155	Aleyassine H, Lee SH "Inhibition of insulin release by substrates and inhibitors of monoamine oxidase." Am J Physiol 222 (1972): 565-9. [PMID: 5022664]
156	Almirall J, Montoliu J, Torras A, Revert L "Propoxyphene-induced hypoglycemia in a patient with chronic renal failure." Nephron 53 (1989): 273-5. [PMID: 2797348]
157	Arauz-Pacheco C, Ramirez LC, Rios JM, Raskin P "Hypoglycemia induced by angiotensin-converting enzyme inhibitors in patients with non-insulin-dependent diabetes receiving sulfonylurea therapy." Am J Med 89 (1990): 811-3. [PMID: 2123605]
158	Baciewicz AM, Swafford WB Jr "Hypoglycemia induced by the interaction of chlorpropamide and co-trimoxazole." Drug Intell Clin Pharm 18 (1984): 309-10. [PMID: 6609055]
159	Barbato M "Another problem with Kinidin." Med J Aust 141 (1984): 685. [PMID: 6436654]
160	Baron SH "Salicylates as hypoglycemic agents." Diabetes Care 5 (1982): 64-71. [PMID: 6754304]
161	Ben Salem C, Fathallah N, Hmouda H, Bouraoui K "Drug-induced hypoglycaemia: an update." Drug Saf 34 (2011): 21-45. [PMID: 20942513]
162	Cacoub P, Deray G, Baumelou A, Grimaldi A, Soubrie C, Jacobs C "Disopyramide-induced hypoglycemia: case report and review of the literature." Fundam Clin Pharmacol 3 (1989): 527-35. [PMID: 2691378]
163	Cattaneo AG, Caviezel F, Pozza G "Pharmacological interaction between tolbutamide and acetylsalicylic acid: study on insulin secretion in man." Int J Clin Pharmacol Ther Toxicol 28 (1990): 229-34. [PMID: 2198232]
164	Christensen LK, Hansen JM, Kristensen M "Sulphaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics." Lancet 2 (1963): 1298-301. [PMID: 14071924]
165	Cooper AJ, Ashcroft G "Potentiation of insulin hypoglycaemia by M.A.O.I. antidepressant drugs." Lancet 1 (1966): 407-9. [PMID: 4159787]
166	Croxson MS, Shaw DW, Henley PG, Gabriel HDLL "Disopyramide-induced hypoglycaemia and increased serum insulin." N Z Med J July (1987): 407-8. [PMID: 3330586]
167	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
168	Daubresse JC, Daigneux D, Bruwier M, Luyckx A, Lefebvre PJ "Clofibrate and diabetes control in patients treated with oral hypoglycaemic agents." Br J Clin Pharmacol 7 (1979): 599-603. [PMID: 380614]
169	Daubresse JC, Luyckx AS, Lefebvre PJ "Potentiation of hypoglycemic effect of sulfonylureas by clofibrate." N Engl J Med 294 (1976): 613. [PMID: 1246250]
170	Davis TM, Karbwang J, Looareesuwan S, et al "Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers." Br J Clin Pharmacol 30 (1990): 397-403. [PMID: 2223418]
171	de Salcedo I, Gorringe AL, Silva JL, Santos JA "Gemfibrozil in a group of diabetics." Proc R Soc Med 69 (1976): 64-70. [PMID: 1019155]
172	Deeg MA, Lipkin EW "Hypoglycemia associated with the use of fluoxetine." West J Med 164 (1996): 262-3. [PMID: 8775944]
173	Feher MD, Amiel S "ACE inhibitors and hypoglycaemia." Lancet 346 (1995): 125-6. [PMID: 7603199]
174	Feldman JM, Chapman B "Monoamine oxidase inhibitors: nature of their interaction with rabbit pancreatic islets to alter insulin secretion." Diabetologia 11 (1975): 487-94. [PMID: 1107123]
175	Ferrari C, Fressati S, Romussi M, et al. "Effects of short-term clofibrate administration on glucose tolerance and insulin secretion in patients with chemical diabetes or hypertriglyceridemia." Metabolism 26 (1977): 129-39. [PMID: 834147]
176	Ferriere M, Lachkar H, Richard JL, Bringer J, Orsetti A, Mirouze J "Captopril and insulin sensitivity." Ann Intern Med 102 (1985): 134-5. [PMID: 3881067]
177	Fogari R, Zoppi A, Corradi L, Pierangelo L, Mugellini A, Lusardi P "Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertension." Br J Clin Pharmacol 46 (1998): 467-71. [PMID: 9833600]
178	Giugliano D, Ceriello A, Saccomanno F, et al "Effects of salicylate, tolbutamide, and prostaglandin E2 on insulin responses to glucose in noninsulin-dependent diabetes mellitus." J Clin Endocrinol Metab 61 (1985): 160-6. [PMID: 3923028]
179	Goldberg IJ, Brown LK, Rayfield EJ "Disopyramide (norpace)-induced hypoglycemia." Am J Med 69 (1980): 463-6. [PMID: 6998294]
180	Harrison LC, King-Roach A, Martin FI, Melick RA "The effect of fenfluramine on insulin binding and on basal and insulin-stimulated oxidation of 1-C-glucose by human adipose tissue." Postgrad Med J 51 Suppl 1 (1975): 110-4. [PMID: 1219664]
181	Hayashi S, Horie M, Tsuura Y, Ishida H, Okada Y, Seino Y, Sasayama S "Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release." Am J Physiol 265 (1993): c337-42. [PMID: 8368263]
182	Hekimsoy Z, Biberoglu S, Comlekci A, Tarhan O, Mermut C, Biberoglu K "Trimethoprim/sulfamethoxazole-induced hypoglycemia in a malnourished patient with severe infection." Eur J Endocrinol 136 (1997): 3046. [PMID: 9100556]
183	Hellman B "Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells." Metabolism 23 (1974): 839-46. [PMID: 4212254]
184	Herings RMC, Deboer A, Stricker BHC, Leufkens HGM, Porsius A "Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme." Lancet 345 (1995): 1195-8. [PMID: 7739305]
185	Hundal RS, Petersen KF, Mayerson AB, et al "Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes." J Clin Invest 109 (2002): 1321-6. [PMID: 12021247]
186	Iida H, Morita T, Suzuki E, Iwasawa K, Toyooka T, Nakajima T "Hypoglycemia induced by interaction between clarithromycin and disopyramide." Jpn Heart J 40 (1999): 91-6. [PMID: 10370402]
187	Johnson J, Dobmeier M "Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction." DICP 24 (1990): 250-1. [PMID: 2316232]
188	Johnson JA, Kappel JE, Sharif MN "Hypoglycemia secondary to trimethoprim/sulfamethoxazole administration in a renal transplant patient." Ann Pharmacother 27 (1993): 304-6. [PMID: 8453166]
189	Konttinen A, Kuisma I, Ralli R, Pohjola S, Ojala K "The effect of gemfibrozil on serum lipids in diabetic patients." Ann Clin Res 11 (1979): 240-5. [PMID: 398183]
190	Kubacka RT, Antla EJ, Juhl RP, Welshman IR "Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects." Ann Pharmacother 30 (1996): 20-6. [PMID: 8773160]
191	Morris AD, Newton RW, Boyle DI, et al. "ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes." Diabetes Care 20 (1997): 1363-7. [PMID: 9283780]
192	Murakami K, Nambu S, Koh H, Kobayashi M, Shigeta Y "Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus." Br J Clin Pharmacol 17 (1984): 89-91. [PMID: 6362704]
193	Nakabayashi H, Ito T, Igawa T, Hiraiwa Y, Imamura T, Seta T, Kawato M, Usukura N, Takeda R "Disopyramide induces insulin secretion and plasma glucose diminution: studies using the in situ canine pancreas." Metabolism 38 (1989): 179-83. [PMID: 2643753]
194	Nappi JM, Dhanani S, Lovejoy JR, VanderArk C "Severe hypoglycemia associated with disopyramide." West J Med 138 (1983): 95-7. [PMID: 6404062]
195	Paolisso G, Balbi V, Gambardella A, Varricchio G, Tortoriello R, Saccomanno F, Amato L, Varricchio M "Lisinopril administration improves insulin action in aged patients with hypertension." J Hum Hypertens 9 (1995): 541-6. [PMID: 7562882]
196	Pestell RG, Crock PA, Ward GM, Alford FP, Best JD "Fenfluramine increases insulin action in patients with NIDDM." Diabetes Care 12 (1989): 252-8. [PMID: 2495916]
197	Phillips AF, Matty PJ, Porte PJ, Raye JR "Inhibition of glucose-induced insulin secretion by indomethacin and sodium salicylate in the fetal lamb." Am J Obstet Gynecol 148 (1984): 481-7. [PMID: 6364813]
198	Phillips RE, Looareesuwan S, White NJ, et al "Hypoglycaemia and antimalarial drugs: quinidine and release of insulin." Br Med J 292 (1986): 1319-21. [PMID: 3085830]
199	Pollak PT, Mukherjee SD, Fraser AD "Sertraline-induced hypoglycemia." Ann Pharmacother 35 (2001): 1371-4. [PMID: 11724085]
200	Prince RL, Larkins RG, Alford FP "The effect of acetylsalicylic acid on plasma glucose and the response of glucose regulatory hormones to intravenous glucose and arginine in insulin treated diabetics and normal subjects." Metabolism 30 (1981): 293-8. [PMID: 7010074]
201	Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
202	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
203	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
204	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
205	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
206	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
207	Quevedo SF, Krauss DS, Chazan JA, et al "Fasting hypoglycemia secondary to disopyramide therapy." JAMA 245 (1981): 2424. [PMID: 6785461]
208	Richardson T, Foster J, Mawer GE "Enhancement by sodium salicylate of the blood glucose lowering effect of chlorpropamide-drug interaction or summation of similar effects." Br J Clin Pharmacol 22 (1986): 43-8. [PMID: 3527244]
209	Rubin M, Zakheim B, Pitchumoni C "Disopyramide-induced profound hypoglycemia." N Y State J Med July,Aug,S (1983): 1057-8. [PMID: 6579404]
210	Salmela PI, Sotaniemi EA, Viikari J, et al "Fenfluramine therapy in non-insulin-dependent diabetic patients effects on body weight, glucose homeostasis, serum lipoproteins, and antipyrine metabolism." Diabetes Care 4 (1981): 535-40. [PMID: 6751729]
211	Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V "Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia." Eur J Clin Nutr 57 (2003): 243-8. [PMID: 12571655]
212	Slade IH, and Iosefa RN "Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases." J Am Geriatr Soc 15 (1967): 948-50. [PMID: 6046558]
213	Storlien LH, Thorburn AW, Smythe GA, Jenkins AB, Chisholm DJ, Kraegen EW "Effect of d-fenfluramine on basal glucose turnover and fat-feeding-induced insulin resistance in rats." Diabetes 38 (1989): 499-503. [PMID: 2647557]
214	Strathman I, Schubert EN, Cohen A, Nitzberg DM "Hypoglycemia in patients receiving disopyramide phosphate." Drug Intell Clin Pharm 17 (1983): 635-8. [PMID: 6413187]
215	Turtle JR, Burgess JA "Hypoglycemic action of fenfluramine in diabetes mellitus." Diabetes 22 (1973): 858-67. [PMID: 4749404]
216	Verdy M, Charbonneau L, Verdy I, Belanger R, Bolte E, Chiasson JL "Fenfluramine in the treatment of non-insulin-dependent diabetics: hypoglycemic versus anorectic effect." Int J Obes 7 (1983): 289-97. [PMID: 6629637]
217	Vuksan V, Sievenpiper JL, Koo VY, et al "American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus." Arch Intern Med 160 (2000): 1009-13. [PMID: 10761967]
218	Vuksan V, Stavro MP, Sievenpiper JL, et al "Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes." Diabetes Care 23 (2000): 1221-6. [PMID: 10977009]
219	Vuorinen-Markkola H, Yki-Jarvinen H "Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus." Metabolism 44 (1995): 85-9. [PMID: 7854171]
220	Whitcroft IA, Thomas JM, Rawsthorne A, et al "Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics." Horm Metab Res Suppl 22 (1990): 42-6. [PMID: 1975246]
221	Wiederholt IC, Genco M, Foley JM "Recurrent episodes of hypoglycemia induced by propoxyphene." Neurology 17 (1967): 703-6. [PMID: 6067489]
222	World Health Organization "WHO Public Assessment Reports (WHOPARs).".
223	Wu B, Sato T, Kiyosue T, Arita M "Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs." Cardiovasc Res 26 (1992): 1095-101. [PMID: 1291087]
224	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
225	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
226	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
227	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
228	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
229	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
230	Product Information. Lyrica (pregabalin). Pfizer U.S. Pharmaceuticals Group, New York, NY.
231	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
232	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
233	Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
234	Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20
235	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
236	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence