Drug General Information (ID: DDIX2V53WR)
Drug Name			Sucralfate		Drug Info		Thyroid, porcine		Drug Info
Drug Type		Small molecule				Hormones
Therapeutic Class		Gi Agents				Thyroid Drugs

Mechanism of Sucralfate-Thyroid, porcine Interaction (Severity Level: Minor)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Thyroid, porcine
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Thyroid, porcine

References
1	Havrankova J, Lahaie R "Levothyroxine binding by sucralfate." Ann Intern Med 117 (1992): 445-6. [PMID: 1503346]
2	Khan F, Jeanniton E, Renedo M "Does sucralfate impede levothyroxine therapy?" Ann Intern Med 118 (1993): 317. [PMID: 8481187]
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]