Details of Drug-Drug Interaction
| Drug General Information (ID: DDIX2KGTBJ) | |||||||||
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| Drug Name | Tolazoline | Drug Info | Silodosin | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Vasodilator Agents | Alpha-Adrenergic Antagonists | |||||||
| Structure | |||||||||
| Mechanism of Tolazoline-Silodosin Interaction (Severity Level: Moderate) | |||||||||
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| Additive hypotensive effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Tolazoline | Silodosin | |||||||
| Mechanism |
Hypotensive effects Alpha-1 adrenergic receptor Antagonist |
Hypotensive effects Alpha-1 adrenergic receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Adrenergic receptor alpha-1 | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | The use of relatively selective alpha-1A adrenoreceptor antagonists in combination with other alpha-blockers should be avoided. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT. | ||||||||||||||||||
| 2 | Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA. | ||||||||||||||||||