Details of Drug

Drug General Information (ID: D1602)
Drug Name	Tolazoline
Drug Type	Small molecule
Drug Synonymous	Artonil; Benzalolin; Benzazoline; Benzidazol; Benzolin; Benzylimidazoline; Divascol; Imidalin; Imidaline; Kasimid;Lambril; Olitensol; Peripherine; Phenylmethylimidazoline; Prefaxil; Pridazole; Priscol; Priscoline; Tolazolin; Tolazolina; Tolazolinum; Vasimid; Vasodil; Vasodilatan; Dilatol ASI; Tolazine [veterinary]; Tolazoline Monohydrochloride; Ciba 3259; Benzolin (VAN); Benzolin (vasodilator); Tolazine [veterinary] (TN); Tolazolina [INN-Spanish]; Tolazoline (INN); Tolazoline [INN:BAN]; Tolazolinum [INN-Latin]; Benzolin (vasodilator) (VAN); 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-(9CI); 2-(phenylmethyl)-4,5-dihydro-1H-imidazole; 2-BENZYL-4,5-IMIDAZOLINE HCl; 2-Benzyl-2-imidazoline; 2-Benzyl-4,5-dihydro-1H-imidazole; 2-Benzyl-4,5-imidazoline; 2-Benzylimidazoline; 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole Click to Show/Hide
Disease Class	BB01: Pulmonary hypertension
Therapeutic Class	Vasodilator Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H12N2
InChI	1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
InChIKey	JIVZKJJQOZQXQB-UHFFFAOYSA-N
Canonical SMILES	C1CN=C(N1)CC2=CC=CC=C2
External Link
	Pubchem ID	5504
	CAS Number	59-98-3
	CHEBI ID	28502
	TTD ID	D03RZV

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM042 Additive hypotensive effects BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Tolazoline
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 62
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[2]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[3], [4], [5]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[17], [18], [19]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[33], [34], [35]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[36], [37]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[10], [12], [14]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[3], [30], [38]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[33], [34], [35]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[17], [39], [40]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[17], [39], [40]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[17], [39], [40]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[39], [41], [42]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[30], [43]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[17], [39], [44]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[39], [41], [42]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[48]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[10], [12], [14]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[49], [50], [51]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[52]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[53], [54], [55]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[56]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[57]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[39], [41], [42]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[36], [37]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[33], [34], [35]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[26], [31], [32]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[39], [41], [42]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0711		Garlic	NA	NA	Minor		Inter Info	[59], [60]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[61], [37]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[45], [46], [47]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[58], [30]

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