Details of Drug

Drug General Information (ID: D1466)
Drug Name	Silodosin
Drug Type	Small molecule
Drug Synonymous	Silodosin; 160970-54-7; Rapaflo; Urief; Silodyx; Urorec; KMD-3213; Silodosin-d6; UNII-CUZ39LUY82; KMD 3213; KAD 3213; CUZ39LUY82; CHEMBL24778; KAD-3213; (R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide; 1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide; 160970-64-9; Q-102517; Rapflo Click to Show/Hide
Disease Class	GA90: Prostate hyperplasia
Therapeutic Class	Alpha-Adrenergic Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C25H32F3N3O4
InChI	1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1
InChIKey	PNCPYILNMDWPEY-QGZVFWFLSA-N
Canonical SMILES	CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
External Link
	Pubchem ID	5312125
	CAS Number	160970-54-7
	CHEBI ID	135929
	TTD ID	D0U0VU
	INTEDE ID	DR1482
	VARIDT ID	DR00285

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM042 Additive hypotensive effects BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Silodosin
Affected cellular transport
	Transporter inhibition					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[2]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[2]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[2]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[2]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[2]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[2]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[2]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[2]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[2]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[22], [61], [62]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[22], [65], [66]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[68]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[22], [70]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[22], [72]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[73]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1], [22], [75]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[22], [76]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[77]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[78]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[80]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[22]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[85]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1], [22], [87], [88]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[2]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[2]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2], [3]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1], [2], [3]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2], [3]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [4]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[2]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[2]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[2]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[2]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[2]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[2]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[2]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[2]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[2]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[2]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[2]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[2]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[2]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1], [22], [52], [53]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[2]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[2]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[60]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[2]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[2]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[2]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[74]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[2]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[2]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[79]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[2]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[2]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[2]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[2]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[2]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[2]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[2]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[2]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[2]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[2]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[2]
	CYP450 enzyme induction					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1], [22], [2]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1], [22], [2]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1], [22], [2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1], [22], [2]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1], [22], [2]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1], [22], [2]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1], [22], [2]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1], [22], [2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[1], [22], [2]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1], [22], [2]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1], [22], [2]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[1], [22], [2]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1], [22], [2]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1], [22], [2]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1], [22], [2]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1], [22], [2]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1], [22], [2]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[1], [22], [2]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1], [22], [2]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[1], [22], [2]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[1], [22], [2]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[1], [22], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[1], [22], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[1], [22], [2]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [22], [2]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1], [22], [2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[22], [69]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [71]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[1], [22], [2]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1], [22], [2]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1], [22], [2]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1], [22], [2]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1], [22], [2]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1], [22], [2]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[1], [22], [2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1], [22], [2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[1], [22], [2]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[1], [22], [2]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1], [22], [2]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [22], [86]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1], [22], [2]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [22], [2]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1], [22], [2]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[1], [22], [2]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1], [22], [2]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1], [22], [2]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 174
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[13], [14], [15]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[16]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[17], [18], [19]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[13], [14], [15]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[20], [9], [21]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[13], [14], [15]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[13], [14], [15]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[13], [14], [15]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[23], [24], [25]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[13], [14], [15]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[34], [9]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[5], [7], [9]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[23], [24], [25]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[23], [24], [25]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[13], [14], [15]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[13], [14], [15]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[13], [14], [15]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[13], [14], [15]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[13], [14], [15]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[13], [14], [15]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[13], [14], [15]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[34], [9]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[13], [14], [15]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[5], [7], [9]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[13], [14], [15]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[13], [14], [15]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[13], [14], [15]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[13], [14], [15]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[13], [14], [15]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[13], [14], [15]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[13], [14], [15]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[13], [14], [15]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[13], [14], [15]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[13], [14], [15]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[13], [14], [15]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[13], [14], [15]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[1], [35], [36]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[13], [14], [15]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[13], [14], [15]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[13], [14], [15]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[13], [14], [15]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[13], [14], [15]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[13], [14], [15]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[13], [14], [15]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[13], [14], [15]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[37], [2]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[13], [14], [15]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[13], [14], [15]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[13], [14], [15]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[34], [9]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[9], [38]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[13], [14], [15]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[13], [14], [15]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[13], [14], [15]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[34], [9]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[1], [22], [39]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[13], [14], [15]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[13], [14], [15]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[13], [14], [15]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[13], [14], [15]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[13], [14], [15]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[13], [14], [15]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[5], [7], [9]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[13], [14], [15]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[34], [9]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[13], [14], [15]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[13], [14], [15]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[13], [14], [15]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[13], [14], [15]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[13], [14], [15]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[13], [14], [15]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[13], [14], [15]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[5], [7], [9]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[13], [14], [15]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[54], [55]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[13], [14], [15]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[34], [9]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[13], [14], [15]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[13], [14], [15]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[13], [14], [15]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[13], [14], [15]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[13], [14], [15]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[13], [14], [15]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[13], [14], [15]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[13], [14], [15]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[13], [14], [15]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[56]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[34], [9]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[37], [2]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[37], [2]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[37], [2]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[13], [14], [15]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[13], [14], [15]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[34], [9]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[34], [9]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[13], [14], [15]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[13], [14], [15]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[2], [58], [59]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[63], [64]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[13], [14], [15]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[1], [22], [67]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[1], [22], [67]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[1], [22], [67]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[5], [7], [9]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[13], [14], [15]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[13], [14], [15]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[81], [82], [83]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[13], [14], [15]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[13], [14], [15]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[13], [14], [15]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[84]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[13], [14], [15]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[13], [14], [15]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[22], [89], [2]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[37], [2]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[13], [14], [15]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[37], [2]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[13], [14], [15]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[5], [7], [9]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[37], [2]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[34], [9]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [9], [50], [51]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[13], [14], [15]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[13], [14], [15]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[13], [14], [15]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[81], [82], [90]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[13], [14], [15]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[26], [27], [28], [29], [17], [30], [18], [31], [19], [32], [33]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[13], [14], [15]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[1], [22], [57]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[91], [9]

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48	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
49	Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
50	Reggev A, Vollhardt BR "Bradycardia induced by an interaction between phenelzine and beta blockers." Psychosomatics 30 (1992): 106-8. [PMID: 2913594]
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53	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
54	Leenen FH, Smith DL, Unger WP "Topical minoxidil: cardiac effects in bald men." Br J Clin Pharmacol 26 (1988): 481-5. [PMID: 3191000]
55	Product Information. Rogaine (minoxidil topical). Johnson and Johnson/McNeil Consumer, Fort Washington, PA.
56	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
57	Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.
58	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
59	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
60	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
61	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
62	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
63	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
64	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
65	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
66	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
67	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
68	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
69	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
70	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
71	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
72	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
73	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
74	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
75	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
76	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
77	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
78	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
79	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
80	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
81	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
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83	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
84	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
85	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
86	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
87	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
88	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
89	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
90	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
91	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.

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