| Mechanism of Memantine-Tromethamine Interaction
(Severity Level: Minor)
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Altered urine pH
Click to Show/Hide Mechanism Graph
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| Drug Name |
Memantine |
Tromethamine |
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Mechanism
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Urine pH sensitive |
Urine alkalinizer
Decrease the renal excretion
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| Key Mechanism Factor 1 |
| Factor Name |
Urine pH |
| Factor Description |
The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion. |
| Mechanism Description |
- Altered elimination of Memantine caused by Tromethamine mediated altered urine pH
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