Details of Drug

Drug General Information (ID: D1654)
Drug Name	Tromethamine
Drug Type	Small molecule
Drug Synonymous	Trometamol; 77-86-1; TROMETHAMINE; Tris; Tris(Hydroxymethyl)aminomethane; Tham; Trisamine; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; Trizma; Tris buffer; Tris base; Tromethane; Trisaminol; Talatrol; Trispuffer; Trisamin; Pehanorm; Tutofusin tris; Tris-steril; Apiroserum Tham; Addex-tham; Tris-base; Tris, free base; Trimethylolaminomethane; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; Tris Amino; Aminotrimethylolmethane; Aminotris(hydroxymethyl)methane; THAM-E; Tris (buffering agent); Tris(Hydroxymethyl)Aminomethane Click to Show/Hide
Disease Class	5C73: Acidosis
Therapeutic Class	Genitourinary Tract Agents
Structure
Structure	3D Structure		2D Structure
Formula	C4H11NO3
InChI	1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChIKey	LENZDBCJOHFCAS-UHFFFAOYSA-N
Canonical SMILES	C(C(CO)(CO)N)O
External Link
	Pubchem ID	6503
	CAS Number	77-86-1
	CHEBI ID	9754
	TTD ID	D03ZFN

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM005 Affected excretion pathways BM029 Altered urine pH
Relation Graph

Full list of drugs interacting with Tromethamine
Affected excretion pathways
	Altered urine pH					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[1], [2], [3]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[4], [5], [6], [7], [8], [9]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[4], [5], [6], [7], [8], [9]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[10], [11], [12]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[4], [5], [6], [7], [8], [9]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[10], [11], [12]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[13], [14], [15]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[13], [14], [15]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[4], [5], [6], [7], [8], [9]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[16]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[4], [8], [9]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[10], [11], [12]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[10], [11], [12]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[13], [14], [15]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[17], [18], [19]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[1], [2], [3]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[20], [21], [1], [2], [3]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[10], [11], [12]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[1], [2], [3]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[22], [23], [24]
D1020		Methenamine	C6H12N4	4101	Moderate		Inter Info	[25], [26], [27], [28], [29]
D0013		Acetohexamide	C15H20N2O4S	1989	Minor		Inter Info	[30], [31], [32]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Minor		Inter Info	[30], [31], [32]
D0664		Flecainide	C17H20F6N2O3	3356	Minor		Inter Info	[33]
D0728		Glipizide	C21H27N5O4S	3478	Minor		Inter Info	[30], [31]
D0730		Glyburide	C23H28ClN3O5S	3488	Minor		Inter Info	[30], [31]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[34]
D1025		Methotrexate	C20H22N8O5	126941	Minor		Inter Info	[35], [29], [36]
D1601		Tolazamide	C14H21N3O3S	5503	Minor		Inter Info	[30], [31], [32]
D1603		Tolbutamide	C12H18N2O3S	5505	Minor		Inter Info	[30], [31], [32]

References
1	Berg KJ "Acute effects of acetylsalicylic acid in patients with chronic renal insufficiency." Eur J Clin Pharmacol 11 (1977): 111-6. [PMID: 837963]
2	Brouwers JRBJ, Desmet PAGM "Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs." Clin Pharmacokinet 27 (1994): 462-85. [PMID: 7882636]
3	Prescott LF, Balali-Mood M, Critchley JA, Johnstone AF, Proudfoot AT "Diuresis or urinary alkalinisation for salicylate poisoning?" Br Med J (Clin Res Ed) 285 (1982): 1383-6. [PMID: 6291695]
4	Anggard E, Jonsson LE, Hogmark AL, Gunne LM "Amphetamine metabolism in amphetamine psychosis." Clin Pharmacol Ther 14 (1973): 870-80. [PMID: 4729903]
5	Beckett AH, Rowland M "Urinary excretion kinetics of amphetamine in man." J Pharm Pharmacol 17 (1965): 628-39. [PMID: 4379686]
6	Beckett AH, Rowland M, Turner P "Influence of urinary pH on excretion of amphetamine." Lancet 1 (1965): 303. [PMID: 14247879]
7	Beckett AH, Salmon JA, Mitchard M "The relation between blood levels and urinary excretion of amphetamine under controlled acidic and under fluctuating urinary pH values using [C]amphetamine." J Pharm Pharmacol 21 (1969): 251-8. [PMID: 4390145]
8	Davis JM, Kopin IJ, Lemberger L, Axelrod J "Effects of urinary pH on amphetamine metabolism." Ann N Y Acad Sci 179 (1971): 493-501. [PMID: 5285389]
9	Wilkinson GR, Beckett AH "Absorption, metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47. [PMID: 5656593]
10	Elliott GR "Sodium bicarbonate and oral tetracycline." Clin Pharmacol Ther 13 (1972): 459. [PMID: 5026384]
11	Jaffe JM, Colaizzi JI, Poust RI, McDonald RH Jr "Effect of altered urinary pH on tetracycline and doxycycline excretion in humans." J Pharmacokinet Biopharm 1 (1973): 267-82.
12	Jaffe JM, Poust RI, Feld SL, Colaizzi JL "Influence of repetitive dosing and altered urinary pH on doxycycline excretion in humans." J Pharm Sci 63 (1974): 1256-60. [PMID: 4852448]
13	Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4. [PMID: 7438686]
14	Kuntzman RG, Tsai I, Brand L, Mark LC "The influence of urinary pH on the plasma half-life of pseudoephedrine in man and dog and a sensitive assay for its determination in human plasma." Clin Pharmacol Ther 12 (1971): 62-7. [PMID: 5541135]
15	Wilkinson GR, Beckett AH "Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47. [PMID: 5656593]
16	Allanby KD, Trounce JR "Excretion of mecamylamine after intravenous and oral administration." Br Med J 2 (1957): 1219-21. [PMID: 13472094]
17	Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
18	Romankiewicz JA, Reidenberg M, Drayer D, Franklin JE "The noninterference of aluminum hydroxide gel with quinidine sulfate absorption: An approach to control quinidine-induced diarrhea." Am Heart J 96 (1978): 518-20
19	Mauro VF, Mauro LS, Fraker TD Jr, Temesy-Armos PN, Somani P "Effect of aluminum hydroxide gel on quinidine gluconate absorption." DICP 24 (1990): 252-4
20	Balali-Mood M, Prescott LF "Failure of alkaline diuresis to enhance diflunisal elimination." Br J Clin Pharmacol 10 (1980): 163-5. [PMID: 7426277]
21	Berg KJ "Acute acetylsalicylic acid poisoning: treatment with forced alkaline diuresis and diuretics." Eur J Clin Pharmacol 12 (1977): 111-6. [PMID: 21797]
22	Parfrey PS, Ikeman R, Anglin D, Cole C. Severe lithium intoxication treated by forced diuresis. Can Med Assoc J. 1983 Nov 1;129(9):979-80
23	Arthur RK "Lithium levels and "Soda Bic"." Med J Aust 2 (1975): 918
24	Thomsen K, Schou M "Renal lithium excretion in man." Am J Psychol 215 (1968): 823-7
25	Kevorkian C, Merritt J, Ilstrup D "Methenamine mandelate with acidification: an effective urinary antiseptic in patients with neurogenic bladder." Mayo Clin Proc 59 (1984): 523. [PMID: 6379319]
26	Musher D, Griffith D "Generation of formaldehyde from methenamine: effect of pH and concentration, and antibacterial effect." Antimicrob Agents Chemother 6 (1974): 708-11. [PMID: 4451344]
27	Product Information. Hiprex (methenamine). Hoechst Marion-Roussel Inc, Kansas City, MO.
28	Product Information. Hyophen (benzoic acid/hyoscy/methen/mblue/phenylsal). BioComp Pharma, San Antonio, TX.
29	Sand TE, Jacobsen S "Effect of urine pH and flow on renal clearance of methotrexate." Eur J Clin Pharmacol 19 (1981): 453-6. [PMID: 7250179]
30	Kivisto KT, Neuvonen PJ "Differential effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide." Eur J Clin Pharmacol 40 (1991): 383-6. [PMID: 1646724]
31	Neuvonen PJ, Karkkainen S "Effects of charcoal, sodium bicarbonate, and ammonium chloride on chlorpropamide kinetics." Clin Pharmacol Ther 33 (1983): 386-93. [PMID: 6297841]
32	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
33	Hertrampf R, Gundert-Remy U, Beckmann J, et al "Elimination of flecainide as a function of urinary flow rate and pH." Eur J Clin Pharmacol 41 (1991): 61-3. [PMID: 1782979]
34	Product Information. Namenda (memantine). Forest Pharmaceuticals, St. Louis, MO.
35	Nirenberg A, Mosende C, Mehta BM, Gisolfi AL, Rosen G "High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity." Cancer Treat Rep 61 (1977): 779-83. [PMID: 302143]
36	Stoller RG, Hande KR, Jacobs SA, Rosenberg SA, Chabner BA "Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity." N Engl J Med 297 (1977): 630-4. [PMID: 302412]

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