Details of Drug-Drug Interaction
| Drug General Information (ID: DDIF1Z8AK2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Flecainide | Drug Info | Tromethamine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiarrhythmic Agents | Genitourinary Tract Agents | |||||||
| Structure | |||||||||
| Mechanism of Flecainide-Tromethamine Interaction (Severity Level: Minor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered urine pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Flecainide | Tromethamine | |||||||
| Mechanism | Urine pH sensitive | Urine alkalinizer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Urine pH | ||||||||
| Factor Description | The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion. | ||||||||
| Mechanism Description |
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| References | |||||||||||||||||||
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| 1 | Hertrampf R, Gundert-Remy U, Beckmann J, et al "Elimination of flecainide as a function of urinary flow rate and pH." Eur J Clin Pharmacol 41 (1991): 61-3. [PMID: 1782979] | ||||||||||||||||||