Drug General Information (ID: DDIUCALHB3)
Drug Name			Ethanol		Drug Info		Abacavir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Anti-Hiv Agents
Structure

Mechanism of Ethanol-Abacavir Interaction (Severity Level: Minor)
Non-CYP450 enzyme inhibition Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Abacavir
Mechanism		Alcohol dehydrogenase inhibitor				Alcohol dehydrogenase substrate
Key Mechanism Factor 1
		Factor Name		Alcohol dehydrogenase				Structure Sequence
		Protein Family		Zinc-containing alcohol dehydrogenase family
		Protein Function		Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060).     Click to Show/Hide
Mechanism Description		Decreased metabolism of Abacavir caused by Ethanol mediated inhibition of non-CYP450 enzyme

References
1	Product Information. Ziagen (abacavir). Glaxo Wellcome, Research Triangle Pk, NC.