Drug General Information (ID: DDITY2AJ7Z)
Drug Name			Didanosine		Drug Info		Elvitegravir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antiviral Agents
Structure

Mechanism of Didanosine-Elvitegravir Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Didanosine				Elvitegravir
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Didanosine due to formation of complexes caused by Elvitegravir

Recommended Action
Management		When prescribed in combination with elvitegravir, didanosine should be administered on an empty stomach one hour before or two hours after elvitegravir, which is to be taken with food. Clinical monitoring for altered therapeutic efficacy is advisable.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".