Details of Drug

Details of Drug

 Drug General Information (ID: D0563)
  Drug Name
Elvitegravir
  Drug Type Small molecule
  Drug Synonymous
EVG
    Click to Show/Hide
  Disease Class 1C60-1C62: Human immunodeficiency virus disease
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C23H23ClFNO5
  InChI 1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1
  InChIKey JUZYLCPPVHEVSV-LJQANCHMSA-N
  Canonical SMILES CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O
  External Link
Pubchem ID 5277135
CAS Number 697761-98-1
CHEBI ID 72289
TTD ID D0QD1G
INTEDE ID DR0570

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM004  Affected intra/extra-hepatic metabolism
BM003  Complex formation
BM009  Altered absorption (Unspecific)
BM022  CYP450 enzyme induction
  Relation Graph
 Full list of drugs interacting with Elvitegravir
      Affected gastrointestinal absorption
   Complex formation Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1722
 
Zinc acetate
 
C4H6O4Zn
 
11192 
Major    Inter Info   
[8], [9], [10]
D1723
 
Zinc chloride
 
Cl2Zn
 
5727 
Major    Inter Info   
[10]
D1724
 
Zinc gluconate
 
C12H22O14Zn
 
443445 
Major    Inter Info   
[8], [9], [10]
D1725
 
Zinc sulfate
 
O4SZn
 
24424 
Major    Inter Info   
[8], [9], [10]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Moderate    Inter Info   
[1], [2]
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1187
 
Orlistat
 
C29H53NO5
 
3034010 
Moderate    Inter Info   
[13]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme induction Drug Num:  37
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[3], [5], [6]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Major    Inter Info   
[7]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Major    Inter Info   
[3], [5], [6]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Major    Inter Info   
[1], [2], [4]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[3], [5], [6]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1], [2], [6]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[1], [2], [6]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[1], [2], [6]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[1], [2], [6]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Moderate    Inter Info   
[1], [11], [12]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[1], [2], [6]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[1], [2], [6]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[1], [2], [6]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[1], [2], [6]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[1], [2], [6]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[1], [2], [6]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[1], [2], [6]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[1], [2], [6]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[1], [2], [6]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Moderate    Inter Info   
[1], [2], [6]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[1], [2], [6]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[1], [2], [6]
D1186
 
Oritavancin
 
C86H97Cl3N10O26
 
16136912 
Moderate    Inter Info   
[1], [2], [6]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[1], [2], [6]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[1], [2], [6]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [6]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[1], [2], [6]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[1], [2], [6]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Genvoya (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
4 Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
5 Product Information. Tybost (cobicistat). Gilead Sciences, Foster City, CA.
6 Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
7 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
8 Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
9 Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
10 US National Library of Medicine "Guidelines for the use of antiretroviral agents in adults and adolescents with HIV.".
11 McAllister WA, Thompson PJ, Al-Habet SM, Rogers HJ. Rifampicin reduces effectiveness and bioavailability of prednisolone.?Br Med J (Clin Res Ed). 1983;286(6369):923-925. [PMID: 6403136]
12 Product Information. Voltaren (diclofenac). Novartis Pharmaceuticals, East Hanover, NJ.
13 MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines.".