Drug General Information (ID: DDITXLAK8S)
Drug Name			Bosutinib		Drug Info		Calcium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antacids/Minerals And Electrolytes
Structure

Mechanism of Bosutinib-Calcium carbonate Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Bosutinib				Calcium carbonate
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Bosutinib due to altered gastric pH caused by Calcium carbonate

Recommended Action
Management		To minimize the potential for interaction, H2-receptor antagonists or antacids should be administered at least 2 hours before or 2 hours after the bosutinib dose.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.