Details of Drug

Drug General Information (ID: D0195)
Drug Name	Bosutinib
Drug Type	Small molecule
Drug Synonymous	SKI 606; SKI606; Bosutinib (USAN); PF-5208763; SKI-606; Xy]-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile; 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; Bosutinib (BCR-ABL inhibitor 3rd gen) Click to Show/Hide
Disease Class	2C60-2C6Y: Breast cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C26H29Cl2N5O3
InChI	1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
InChIKey	UBPYILGKFZZVDX-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
External Link
	Pubchem ID	5328940
	CAS Number	380843-75-4
	CHEBI ID	39112
	TTD ID	D0OB0F
	INTEDE ID	DR0224
	VARIDT ID	DR00253

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM005 Altered gastric pH BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Bosutinib
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[9], [21]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[9], [21]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[9], [21]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[9], [21]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[9], [21]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[9], [21]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[9], [21]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[21]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[21]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[9], [21]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[21]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[9], [21]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[9], [21]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[21]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[21]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[21]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[9], [21]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[9], [21]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[9], [21]
Affected cellular transport
	Transporter inhibition					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[9], [21]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[9], [21]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[9], [21]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[9], [21]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[9], [21]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[9], [252]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[253]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[9], [21]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[9], [21]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[9], [21]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[275]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[9], [21]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[9], [21]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[9], [21]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[9], [21]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[9], [21]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[9], [21]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[9], [21]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[9], [21]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[8], [9], [21], [22]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[8], [9], [21], [22]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[8], [9], [21], [22]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[8], [9], [21], [22]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[8], [9], [21], [22]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[8], [9], [21], [22]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[8], [9], [21], [22]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[8], [9], [21], [22]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[8], [9], [21], [22]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[8], [9], [21]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[8], [9], [21], [22]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[8], [9], [21], [22]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[8], [9], [21]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[7], [8], [9], [46], [47], [48], [19]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[8], [9], [21], [22]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[8], [9], [21], [22]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[8], [9], [21], [22]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[8], [9], [21], [22]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[8], [9], [21], [22]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[8], [9], [21], [22]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[8], [9], [21], [22]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[8], [9], [21]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[8], [9], [21], [22]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[8], [9], [21], [22]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[8], [9], [21], [22]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[8], [9], [21], [22]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[8], [9], [21], [22]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[8], [9], [21], [22]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[8], [9], [21], [22]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[8], [9], [21], [22]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[8], [9], [21], [22]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[8], [9], [21], [22]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[8], [9], [21], [22]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[8], [9], [21], [22]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[8], [9], [21], [22]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[8], [9], [21], [22]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[8], [9], [21], [22]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[8], [9], [21], [22]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[8], [9], [21], [22]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[8], [9], [21], [22]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[8], [9], [21], [22]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[8], [9], [21], [22]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[9], [21]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[228]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[9], [21]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[249]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[9], [21]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[9], [21]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[9], [21]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[9], [21]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[9], [21]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[9], [21]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[9], [21]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[9], [21]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[9], [21]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[9], [21]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[9], [21]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[9], [21]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[9], [21]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[9], [21]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[301]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[9], [21]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[9], [21]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[9], [21]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[9], [21]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[9], [21]
	CYP450 enzyme induction					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[21]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[21]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[21]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[21]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[9], [21]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[21]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[21]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[21]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[21]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[21]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[21]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[21]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[21]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[21]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[21]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[21]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[21]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[9], [21]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[21]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[21]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[21]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[21]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[21]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[21]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[9], [242]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[8], [246]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[21]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[277], [21], [278]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[21]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[280]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[9], [281]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[21]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[21]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[21]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[21]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[277], [21], [278]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[21]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[21]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[21]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[21]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[21]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[21]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[277], [21], [278]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[21]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[244]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[282]
	Additive immunosuppressive effects					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[8], [9], [29]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[55]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[56]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[9], [82]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[140]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[51], [172], [173]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[176], [177], [178]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[8], [9]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[243]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[245]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[245]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[245]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[254]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[255]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[9], [256]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[271]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[276]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[8], [9], [279]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[176], [177], [178]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[288]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[303]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[304]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[176], [177], [178]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[9], [324]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[329]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[330]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[8], [9], [331]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[8], [32], [33]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[151]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[174]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[8], [9], [292], [293]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[8], [9], [292], [293]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[39]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[45]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[54]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[54]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[139]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[217], [218], [219], [8], [9], [220], [221], [222], [223], [224], [225], [226], [227]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[217], [218], [219], [8], [9], [220], [221], [222], [223], [224], [225], [226], [227]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[237]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[217], [218], [219], [8], [9], [220], [221], [222], [223], [224], [225], [226], [227]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[9], [241]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[258], [259], [260], [261]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[8], [9], [272], [273], [274]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[283]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[258], [259], [260], [261]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[258], [259], [260], [261]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[9], [298]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[300]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[217], [218], [219], [8], [9], [220], [221], [222], [223], [224], [225], [226], [227]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[327], [328]
	Increased risk of prolong QT interval					Drug Num: 117
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[7], [8], [9], [23]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[30]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[9], [31]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[38]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[8], [9], [40]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[41]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[42]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[7], [8], [9], [44]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[9], [49]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[7], [8], [9], [57]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[58], [9], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[7], [8], [9], [77], [78], [79]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[7], [8], [9], [80], [81], [19], [35]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[7], [8], [9], [83]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[7], [8], [9], [84]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[7], [8], [9], [85], [86], [19]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[7], [87], [8], [9], [88], [89], [19]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[90], [91], [92], [7], [8], [9], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[113], [7], [8], [9], [114], [115], [116], [117], [118]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[7], [8], [9], [119], [120], [121], [122], [123], [124], [19]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[58], [9], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[7], [8], [9], [125]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[7], [8], [9], [126], [19]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[9], [127], [19]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[7], [8], [9], [128], [19]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[7], [8], [9], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [19]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[90], [91], [92], [7], [8], [9], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[141]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[142], [143], [144], [145], [146], [147], [148], [149]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[9], [85], [150], [19]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[7], [8], [9], [152], [85], [153], [154], [155], [19]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[7], [8], [9], [156]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[7], [8], [9], [157]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[7], [8], [9], [85], [158], [19]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[9], [48]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[9], [175], [48]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[7], [8], [9], [179], [19]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[8], [9], [210], [211], [212], [213], [214], [215]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[7], [8], [9], [216], [19]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[9], [48]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[9], [48]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[9], [48]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[247]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[8], [9], [248]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[9], [48]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[250]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[251]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[9], [48]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[9], [257]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[9], [48]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[9], [48]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[9], [48]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[9], [48]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[9], [48]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[284]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[9], [48]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[9], [175], [48]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[9], [48]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[9], [48]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[91], [99], [100], [105], [294]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[9], [48]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[9], [48]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[9], [48]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[9], [295]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[9], [48]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[9]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[7], [8], [9], [296], [19]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[9], [48]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[9], [48]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[9], [48]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[299]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[9], [159], [160], [161], [162], [163], [164], [165]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[9], [48]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[9], [48]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[8], [9], [302]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[9], [48]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[9], [48]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[9], [48]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[9], [48]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[9], [48]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[9], [48]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[307], [308]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[309]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[9], [48]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[9], [48]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[9], [48]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[310], [311], [312], [313], [314], [315], [316], [317], [318], [319]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[7], [8], [9], [85], [320], [321], [322], [323], [19]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[9], [48]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[7], [8], [9], [325]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[9], [48]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[9], [48]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[9], [48]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[9], [48]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[7], [8], [9], [326], [19]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[9], [48]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[9], [48]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[9], [48]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[9], [48]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[9], [48]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[8], [332], [333], [334]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[7], [8], [9], [335], [336], [337], [338]
	Increased risk of ventricular arrhythmias					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[20]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[24], [25]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[34], [35]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[9], [36], [37]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [43]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[8], [50]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[7], [166], [8], [9], [167], [168], [169], [77], [170], [171]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[8], [9], [236]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[193], [203], [206]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[9], [269], [270]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[8], [9], [236]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[9], [269], [270]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[193], [203], [206]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[7], [8], [9], [285], [286], [287]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[7], [8], [9], [285], [286], [287]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[193], [203], [206]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[193], [203], [206]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[7], [8], [9], [234], [235], [236]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[7], [8], [9], [285], [286], [287]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[193], [203], [206]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[7], [8], [9], [285], [286], [287]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[26], [27], [28]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[26], [27], [28]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[26], [27], [28]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[26], [27], [28]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[26], [27], [28]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[51], [8], [52]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[53]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[26], [27], [28]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[26], [27], [28]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[26], [27], [28]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[51], [229], [230]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[51], [229], [230]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[51], [229], [230]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[51], [229], [230]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[51], [229], [230]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[51], [229], [230]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[51], [229], [230]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[51], [229], [230]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[262], [51], [8], [263], [264], [265], [229], [266], [267], [268], [230]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[51], [229], [230]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[51], [229], [230]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[51], [229], [230]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[297]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[231], [232], [233]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[231], [232], [233]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[238], [239], [240]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[238], [239], [240]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[238], [239], [240]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[238], [239], [240]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[289], [290], [291]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[305], [306]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[289], [290], [291]

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195	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
196	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
197	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
198	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
199	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
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201	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
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216	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
217	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
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223	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
224	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
225	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
226	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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228	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
229	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
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238	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
239	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
240	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
241	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
242	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
243	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
244	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
245	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
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247	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
248	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
249	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
250	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
251	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
252	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
253	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
254	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
255	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
256	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
257	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
258	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
259	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
260	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
261	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
262	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
263	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
264	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
265	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
266	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
267	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
268	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
269	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
270	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
271	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
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273	Gilead Sciences, Inc "About Remdesivir.".
274	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
275	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
276	AnazaoHealth Corporation "P32 Sodium Phosphate."
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280	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
281	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
282	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
283	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
284	Product Information. Lamprene (clofazimine). Novartis Pharmaceuticals, East Hanover, NJ.
285	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
286	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
287	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
288	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
289	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
290	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
291	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
292	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
293	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
294	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
295	Product Information. Besponsa (inotuzumab ozogamicin). Wyeth Laboratories, Philadelphia, PA.
296	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
297	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
298	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
299	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
300	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
301	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
302	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
303	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
304	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
305	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
306	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
307	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
308	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
309	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
310	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
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320	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
321	Sala M, Vicentini A, Brambilla P, et al. "QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy." Ann Gen Psychiatry 4 (2005): 1. [PMID: 15845138]
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324	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
325	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
326	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
327	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
328	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
329	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
330	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
331	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
332	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
333	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
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