Drug General Information (ID: DDIL7P2KB0)
Drug Name			Pantoprazole		Drug Info		Bosutinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Antineoplastics
Structure

Mechanism of Pantoprazole-Bosutinib Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Pantoprazole				Bosutinib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Bosutinib due to altered gastric pH caused by Pantoprazole

Recommended Action
Management		The concomitant use of bosutinib with proton pump inhibitors should generally be avoided. If acid-suppression therapy is required during bosutinib treatment, an H2-receptor antagonist (e.g., cimetidine, famotidine, ranitidine) or antacid may be taken up to 2 hours before or 2 hours after the bosutinib dose.

References
1	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.