Drug General Information (ID: DDITQ1FKY2)
Drug Name			Ethanol		Drug Info		Dihydrocodeine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Narcotic Analgesics
Structure

Mechanism of Ethanol-Dihydrocodeine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Dihydrocodeine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Ethanol and Dihydrocodeine

Recommended Action
Management		Concomitant use of opioid analgesics with ethanol should be avoided.

References
1	Edwards C, Gard PR, Handley SL, Hunter M, Whittington RM "Distalgesic and ethanol-impaired function." Lancet 2 (1982): 384. [PMID: 6124782]
2	Sturner WQ, Garriott JC "Deaths involving propoxyphene: a study of 41 cases over a two-year period." JAMA 223 (1973): 1125-30. [PMID: 4739371]
3	Rosser WW "The interaction of propoxyphene with other drugs." Can Med Assoc J 122 (1980): 149-50. [PMID: 7363204]