Details of Drug

Drug General Information (ID: D0493)
Drug Name	Dihydrocodeine
Drug Type	Small molecule
Drug Synonymous	Dihydrocodeine bitartrate; DF 118; Dihydrocodeine (oral); S-8115; Dihydrocodeine (oral), Shionogi; (-)-Dihydrocodeine Click to Show/Hide
Disease Class	MG30: Chronic pain
Therapeutic Class	Narcotic Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C18H23NO3
InChI	1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
InChIKey	RBOXVHNMENFORY-DNJOTXNNSA-N
Canonical SMILES	CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(CC4)O
External Link
	Pubchem ID	5284543
	CAS Number	125-28-0
	CHEBI ID	135276
	TTD ID	D0T6RC
	INTEDE ID	DR0500

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM035 Additive antimotility effects BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM046 Additive serotonergic effects BM054 Increased risk of GI mucosal injury/bleeding risk BM067 Increased risk of hyponatremia BM069 Increased risk of lowers seizure threshold BM083 Potentiated the pharmacological effects (Unspecific) BM096 Antagonize the effect of opioid receptor agonists BM097 Antagonize the effect of prokinetic agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Dihydrocodeine
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[30], [21], [60]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[30], [21], [60]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[30], [21], [60]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1840		Mebrofenin	C15H19BrN2O5	54158	Moderate		Inter Info	[113], [114], [115]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[47], [48]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[54]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[30], [58], [59]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[61], [62]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[63], [64]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[30], [65]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[72]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[79]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[80]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[21], [84], [76]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[85], [86]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[87], [88]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[89]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[93], [61], [94]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[47], [48]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[99]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[21], [100]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[101], [102], [103]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[21], [87], [104]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[105], [106], [107]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[30], [21], [108]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[26], [110], [56]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[111]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[112]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[116], [56]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[120], [121], [122]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[123]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[126], [56]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[129]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[130]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[93], [61], [131]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[30], [21], [140]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[26], [141], [56]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[21], [148], [149]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[163], [56], [164]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[165], [166], [167]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[169], [170], [171]
	CYP450 enzyme induction					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[53], [30], [21]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[53], [30], [21]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[53], [30], [21]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[21], [75], [76]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[25], [82], [26]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[83]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[53], [30], [21]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[30], [90]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[53], [30], [21]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[53], [30], [21]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[53], [30], [21]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[53], [30], [21]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[21], [117]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[21], [124], [125]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[30], [21], [127]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[30], [21], [127]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[61], [128]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[53], [30], [21]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[53], [30], [21]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[53], [30], [21]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[53], [30], [21]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[53], [30], [21]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[53], [30], [21]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[152], [153], [154]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[53], [30], [21]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[53], [30], [21]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[53], [30], [21]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[53], [30], [21]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[30], [21], [127]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[172], [173], [174]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[172], [173], [174]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[158], [159], [56]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[158], [159], [56]
Pharmacodynamic additive effects
	Additive antimotility effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0186		Bismuth subgallate	C7H6BiO6	16682999	Moderate		Inter Info	[21]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[21]
	Additive cardiorespiratory depression effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[25]
D0445		Desflurane	C3H2F6O	42113	Moderate		Inter Info	[66], [67], [68]
D0698		Fospropofol	C13H21O5P	3038498	Moderate		Inter Info	[96], [97], [98]
D1149		Nitrous oxide	N2O	948	Moderate		Inter Info	[66], [67], [68]
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[66], [67], [68]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[66], [67], [68]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[66], [67], [68]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[66], [67], [68]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[96], [97], [98]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[25]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[25]
	Additive CNS depression effects					Drug Num: 247
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Major		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Major		Inter Info	[1]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Major		Inter Info	[1]
D0143		Baclofen	C10H12ClNO2	2284	Major		Inter Info	[1]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Major		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Major		Inter Info	[1]
D0263		Carisoprodol	C12H24N2O4	2576	Major		Inter Info	[1]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Major		Inter Info	[1]
D0318		Chlormezanone	C11H12ClNO3S	2717	Major		Inter Info	[1]
D0322		Chlorphenesin	C9H11ClO3	7697	Major		Inter Info	[1]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Major		Inter Info	[1]
D0356		Clobazam	C16H13ClN2O2	2789	Major		Inter Info	[1]
D0362		Clonazepam	C15H10ClN3O3	2802	Major		Inter Info	[1]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Major		Inter Info	[1]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[1]
D0417		Dantrolene	C14H10N4O5	6914273	Major		Inter Info	[1]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[8], [9], [10]
D0471		Diamorphine	C21H23NO5	5462328	Major		Inter Info	[1]
D0473		Diazepam	C16H13ClN2O	3016	Major		Inter Info	[1]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[1]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[1]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Major		Inter Info	[1]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[1]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[1]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[1]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[16], [17], [18]
D1084		Molindone	C16H24N2O2	23897	Major		Inter Info	[1]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[16], [17], [18]
D1224		Paraldehyde	C6H12O3	31264	Major		Inter Info	[1]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1]
D1367		Quazepam	C17H11ClF4N2S	4999	Major		Inter Info	[1]
D1391		Remimazolam	C21H19BrN4O2	9867812	Major		Inter Info	[1]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[19], [20], [21]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[1]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[1]
D1576		Thiothixene	C23H29N3O2S2	941651	Major		Inter Info	[1]
D0604		Estazolam	C16H11ClN4	3261	Major		Inter Info	[1]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[1]
D0618		Ethchlorvynol	C7H9ClO	5281077	Major		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1]
D0679		Flurazepam	C21H23ClFN3O	3393	Major		Inter Info	[1]
D0705		Gabapentin	C9H17NO2	3446	Major		Inter Info	[22], [23], [24]
D0748		Halazepam	C17H12ClF3N2O	31640	Major		Inter Info	[1]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[1]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[16], [17], [18]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[1]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[16], [17], [18]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Major		Inter Info	[1]
D0957		Loxapine	C18H18ClN3O	3964	Major		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1]
D1005		Meprobamate	C9H18N2O4	4064	Major		Inter Info	[1]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1]
D1014		Metaxalone	C12H15NO3	15459	Major		Inter Info	[1]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1]
D1023		Methocarbamol	C11H15NO5	4107	Major		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Major		Inter Info	[1]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[1]
D1166		Olanzapine	C17H20N4S	135398745	Major		Inter Info	[1]
D1188		Orphenadrine	C18H23NO	4601	Major		Inter Info	[1]
D1197		Oxazepam	C15H11ClN2O2	4616	Major		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Major		Inter Info	[1]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[16], [28], [29]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[1]
D1335		Pregabalin	C8H17NO2	5486971	Major		Inter Info	[22], [23], [24]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[16], [17], [18]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1]
D1355		Propiomazine	C20H24N2OS	4940	Major		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1]
D1378		Ramelteon	C16H21NO2	208902	Major		Inter Info	[1]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Major		Inter Info	[1]
D1547		Temazepam	C16H13ClN2O2	5391	Major		Inter Info	[1]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[16], [28], [29]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[1]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1]
D1716		Zaleplon	C17H15N5O	5719	Major		Inter Info	[1]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1]
D1729		Zolpidem	C19H21N3O	5732	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[36], [21], [37]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[38], [39], [40]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[41], [42], [43]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[41], [42], [43]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[41], [42], [43]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[44], [11]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[45], [21], [46]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[49], [50], [51]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[38], [39], [40]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[38], [39], [40]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[52]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[52]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[21]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[45], [21], [46]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[45], [21], [46]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[38], [39], [40]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[38], [39], [40]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[38], [39], [40]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[55], [56], [57]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[38], [39], [40]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[41], [42], [43]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[38], [39], [40]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[49], [50], [51]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[41], [42], [43]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[38], [39], [40]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[38], [39], [40]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[49], [50], [51]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[41], [42], [43]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[38], [39], [40]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[41], [42], [43]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[38], [39], [40]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[41], [42], [43]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[49], [50], [51]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[49], [50], [51]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[25], [81], [26]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[38], [39], [40]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[38], [39], [40]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[38], [39], [40]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[38], [39], [40]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[41], [42], [43]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[38], [39], [40]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[56], [92], [26]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[38], [39], [40]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[49], [50], [51]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[56], [95]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[56], [26], [109]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[55], [56], [57]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[41], [42], [43]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[41], [42], [43]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[49], [50], [51]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[38], [39], [40]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[51], [50], [49]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[38], [39], [40]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[41], [42], [43]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[38], [39], [40]
D1183		Opium	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1200		Oxitriptan	C11H12N2O3	439280	Moderate		Inter Info	[41], [42], [43]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[38], [39], [40]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[38], [39], [40]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[38], [39], [40]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[49], [50], [51]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[38], [39], [40]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[38], [39], [40]
D1675		Valerian	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[41], [42], [43]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[43], [42], [41]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[38], [39], [40]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[38], [39], [40]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[38], [39], [40]
D0514		Dolasetron	C19H20N2O3	3033818	Moderate		Inter Info	[41], [42], [43]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[41], [42], [43]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[41], [42], [43]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[38], [39], [40]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[38], [39], [40]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[38], [39], [40]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[41], [42], [43]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[38], [39], [40]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[41], [42], [43]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[132], [133], [134]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[38], [39], [40]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[38], [39], [40]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[38], [39], [40]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[41], [42], [43]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[41], [42], [43]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[41], [42], [43]
D0702		Frovatriptan	C14H17N3O	77992	Moderate		Inter Info	[41], [42], [43]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[49], [50], [51]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[41], [42], [43]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[138], [56], [139]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[41], [42], [43]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[38], [39], [40]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[38], [39], [40]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[38], [39], [40]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[38], [39], [40]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[21]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[41], [42], [43]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[38], [39], [40]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[38], [39], [40]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[38], [39], [40]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[145], [146], [147]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[38], [39], [40]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[38], [39], [40]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[41], [42], [43]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[38], [39], [40]
D1110		Naratriptan	C17H25N3O2S	4440	Moderate		Inter Info	[41], [42], [43]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[41], [42], [43]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[41], [42], [43]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[56], [151], [26]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[41], [42], [43]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[49], [50], [51]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[41], [42], [43]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[38], [39], [40]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[41], [42], [43]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[38], [39], [40]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[38], [39], [40]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[38], [39], [40]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[38], [39], [40]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[38], [39], [40]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[52]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[38], [39], [40]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[49], [50], [51]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[41], [42], [43]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[38], [39], [40]
D1419		Rizatriptan	C15H19N5	5078	Moderate		Inter Info	[41], [42], [43]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[38], [39], [40]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[49], [50], [51]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[43], [42], [41]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[160], [161], [162]
D1521		Sumatriptan	C14H21N3O2S	5358	Moderate		Inter Info	[41], [42], [43]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[56], [26], [168]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[38], [39], [40]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[38], [39], [40]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[38], [39], [40]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[49], [50], [51]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[38], [39], [40]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[41], [42], [43]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[52]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[38], [39], [40]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[38], [39], [40]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[41], [42], [43]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[38], [39], [40]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[38], [39], [40]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[51], [50], [49]
D1658		Tryptophan	C11H12N2O2	6305	Moderate		Inter Info	[41], [42], [43]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[38], [39], [40]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[38], [39], [40]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[41], [42], [43]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[38], [39], [40]
	Additive hypotensive effects					Drug Num: 79
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[2], [3], [4]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[2], [3], [4]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[2], [3], [4]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[2], [3], [4]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[2], [3], [4]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[26], [32], [11]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[33], [34], [35]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[33], [34], [35]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[33], [34], [35]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[33], [34], [35]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[33], [34], [35]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[33], [34], [35]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[33], [34], [35]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[33], [34], [35]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[33], [34], [35]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[33], [34], [35]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[33], [34], [35]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[33], [34], [35]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[33], [34], [35]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[33], [34], [35]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[33], [34], [35]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[33], [34], [35]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[33], [34], [35]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[33], [34], [35]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[33], [34], [35]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[33], [34], [35]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[33], [34], [35]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[33], [34], [35]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[33], [34], [35]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[33], [34], [35]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[33], [34], [35]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[33], [34], [35]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[33], [34], [35]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[33], [34], [35]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[33], [34], [35]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[33], [34], [35]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[33], [34], [35]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[33], [34], [35]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[33], [34], [35]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[33], [34], [35]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[33], [34], [35]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[33], [34], [35]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[33], [34], [35]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[33], [34], [35]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[33], [34], [35]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[33], [34], [35]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[33], [34], [35]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[33], [34], [35]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[33], [34], [35]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[33], [34], [35]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[33], [34], [35]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[33], [34], [35]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[33], [34], [35]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[33], [34], [35]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[33], [34], [35]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[33], [34], [35]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[33], [34], [35]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[33], [34], [35]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[33], [34], [35]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[33], [34], [35]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[33], [34], [35]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[33], [34], [35]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[33], [34], [35]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[33], [34], [35]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[33], [34], [35]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[33], [34], [35]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[33], [34], [35]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[33], [34], [35]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[33], [34], [35]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[33], [34], [35]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[33], [34], [35]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[33], [34], [35]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[33], [34], [35]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[33], [34], [35]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[33], [34], [35]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[33], [34], [35]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[33], [34], [35]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[33], [34], [35]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[33], [34], [35]
	Additive serotonergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[30], [21], [31]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0146		Baricitinib	C16H17N7O2S	44205240	Moderate		Inter Info	[77], [78]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[77], [78]
	Increased risk of hyponatremia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[69], [70], [71]
	Increased risk of lowers seizure threshold					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[5], [6], [7]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[13], [14], [15]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[13], [14], [15]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[73], [74]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[118], [119], [21]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[135], [136], [137]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[142], [143], [144]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[156], [157]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[21], [91]
Pharmacodynamic antagonistic effects
	Antagonize the effect of opioid receptor agonists					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0050		Alvimopan	C25H32N2O4	5488548	Major		Inter Info	[11], [12]
D1106		Naltrexone	C20H23NO4	5360515	Major		Inter Info	[25], [26], [27]
D1105		Naloxone	C19H21NO4	5284596	Moderate		Inter Info	[30], [25], [150]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1862		Pegvisomant	NA	NA	Moderate		Inter Info	[25], [26], [155]

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