Drug General Information (ID: DDITNEPAOU)
Drug Name			Ethanol		Drug Info		Eluxadoline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Peripheral Opioid Receptor Mixed Agonists/Antagonists
Structure

Mechanism of Ethanol-Eluxadoline Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Eluxadoline
Mechanism		Pancreatic toxicity				Pancreatic toxicity
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Ethanol and Eluxadoline

Recommended Action
Management		Chronic or acute excessive use of alcohol should be avoided during treatment with eluxadoline. Alcoholism, alcohol abuse, alcohol addiction, and consumption of more than 3 alcoholic beverages per day are considered contraindications to the use of eluxadoline. Patients should be advised to stop taking eluxadoline and seek medical attention if they experience potential symptoms of pancreatitis such as persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, especially that which is made worse after eating or radiates to the back or shoulders.

References
1	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.