Details of Drug

Drug General Information (ID: D0562)
Drug Name	Eluxadoline
Drug Type	Small molecule
Drug Synonymous	MuDelta Click to Show/Hide
Disease Class	DD91: Irritable bowel syndrome
Therapeutic Class	Peripheral Opioid Receptor Mixed Agonists/Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C32H35N5O5
InChI	1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1
InChIKey	QFNHIDANIVGXPE-FNZWTVRRSA-N
Canonical SMILES	CC1=CC(=CC(=C1CC(C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)C(C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N
External Link
	Pubchem ID	11250029
	CAS Number	864821-90-9
	CHEBI ID	85980
	TTD ID	D09ZXR
	VARIDT ID	DR00149

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Eluxadoline
Affected cellular transport
	Transporter inhibition					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2], [3]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[1], [2], [3]
D0561		Eltrombopag	C25H22N4O4	135449332	Major		Inter Info	[1], [2], [3]
D0109		Artesunate	C19H28O8	6917864	Major		Inter Info	[1], [2], [3]
D0425		Darolutamide	C19H19ClN6O2	67171867	Major		Inter Info	[1], [2], [3]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[1], [5], [6]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1], [2], [3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2], [3]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [2], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[1], [2], [3]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[1], [2], [3]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[7], [5], [8]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[9]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[10]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[11]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[12], [1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[3]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[3]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[3]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[3]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[3]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[3]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[3]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[3]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[3]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[3]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[3]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[3]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[3]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[3]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[3]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[3]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[3]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[3]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[3]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[3]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[3]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[3]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[3]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[3]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[3]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[3]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[3]
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 113
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1], [4]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[3]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[1], [3]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[1], [3]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[1], [3]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[1], [3]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1], [3]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[1], [3]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[1], [3]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[1], [3]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[1], [3]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[1], [3]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[1], [3]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1], [3]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[1], [3]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[1], [3]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[1], [3]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[1], [3]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1], [3]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[1], [3]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[1], [3]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[1], [3]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[1], [3]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[1], [3]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[1], [3]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[1], [3]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[1], [3]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[1], [3]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[1], [3]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[1], [3]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[1], [3]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[1], [3]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[1], [3]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[1], [3]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[1], [3]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[1], [3]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[1], [3]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[1], [3]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[1], [3]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[1], [3]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[1], [3]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[1], [3]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[1], [3]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[1], [3]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[1], [3]
D1183		Opium	NA	NA	Moderate		Inter Info	[1], [3]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[1], [3]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[1], [3]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[1], [3]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[1], [3]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1], [3]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[1], [3]
D0734		Glycopyrronium (topical)	C19H28NO3+	3494	Moderate		Inter Info	[1], [3]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1], [3]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[1], [3]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[1], [3]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[1], [3]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[1], [3]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[1], [3]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[1], [3]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[1], [3]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[1], [3]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[1], [3]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[1], [3]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[1], [3]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[1], [3]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[1], [3]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[1], [3]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[1], [3]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[1], [3]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[1], [3]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[1], [3]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[1], [3]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[1], [3]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[1], [3]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[1], [3]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[1], [3]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[1], [3]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[1], [3]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[1], [3]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[1], [3]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[1], [3]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[1], [3]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[1], [3]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[1], [3]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[1], [3]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[1], [3]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[1], [3]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[1], [3]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[1], [3]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[1], [3]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[1], [3]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1], [3]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[1], [3]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[1], [3]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[1], [3]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[1], [3]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[1], [3]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[1], [3]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[1], [3]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[1], [3]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[1], [3]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[1], [3]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[1], [3]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[1], [3]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[1], [3]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[1], [3]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[1], [3]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[1], [3]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[1], [3]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[1], [3]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[1], [3]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[1], [3]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Davenport JM, Covington P, Bonifacio L, McIntyre G, Venitz J "Effect of uptake transporters OAT3 and OATPIBI and efflux transporter MRP2 on the pharmacokinetics of eluxadoline." J Clin Pharmacol 55 (2015): 534-42. [PMID: 25491493]
3	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
4	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
5	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
6	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
7	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
8	Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
9	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
10	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
11	Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
12	Cerner Multum, Inc. "Australian Product Information.".

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