Drug General Information (ID: DDITJDLO9E)
Drug Name			Magnesium oxide		Drug Info		Patiromer		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Minerals And Electrolytes				Cation Exchange Resins

Mechanism of Magnesium oxide-Patiromer Interaction (Severity Level: Major)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Magnesium oxide				Patiromer
Mechanism		Binds to cation exchange resin/polymer				Cation exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Patiromer due to formation of complexes caused by Magnesium oxide

Recommended Action
Management		Nonabsorbable calcium, magnesium, or aluminum preparations such as antacids or laxatives should not be used in patients receiving oral cation-exchange resins. alternatively, the interaction may be avoided by administering the resin as an enema.

References
1	Product Information. Resonium Calcium (calcium polystyrene sulfonate). Sanofi-Synthelabo Canada Inc, Markham, ON.
2	Ziessman HA "Alkalosis and seizure due to a cation-exchange resin and magnesium hydroxide." South Med J 69 (1976): 497-9.[PMID: 817399]
3	Madias NE, Levey AS "Metabolic alkalosis due to absorption of "nonabsorbable" antacids." Am J Med 74 (1983): 155-8.[PMID: 6849324]