Details of Drug

Drug General Information (ID: D1231)
Drug Name		Patiromer
Drug Type		Small molecule
Drug Synonymous		DB09263; Patiromer; Patiromer FOS Click to Show/Hide
Therapeutic Class		Cation Exchange Resins

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects BM003 Complex formation BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Patiromer
Affected gastrointestinal absorption
	Complex formation					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Major		Inter Info	[1], [2], [3]
D0236		Calcium carbonate	CCaO3	10112	Major		Inter Info	[1], [2], [3]
D0967		Magaldrate	AlHMgO5S+2	3086011	Major		Inter Info	[1], [2], [3]
D0973		Magnesium hydroxide	H2MgO2	14791	Major		Inter Info	[1], [2], [3]
D0974		Magnesium oxide	MgO	14792	Major		Inter Info	[1], [2], [3]
D0968		Magnesium carbonate	CMgO3	11029	Major		Inter Info	[1], [2], [3]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[10]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[22], [23], [24]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[22], [23], [24]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[22], [23], [24]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[10]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[22], [23], [24]
Pharmacodynamic additive effects
	Increased risk of hypokalemia					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[17], [18], [19]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[17], [18], [19]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[17], [18], [19]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[17], [18], [19]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[17], [18], [19]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[17], [18], [19]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[17], [18], [19]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[17], [18], [19]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[17], [18], [19]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[17], [18], [19]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[17], [18], [19]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[17], [18], [19]
	Increased risk of hypomagnesemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[20]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[20]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[20]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[20]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[20]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[20]
	Increased risk of ventricular arrhythmias					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[4], [5]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[6], [7]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[8]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[9], [10], [11], [12], [13], [14]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[15]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[16]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[10], [11]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[10], [11]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[11], [21]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[10], [11]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[10], [11]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[10], [11]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[10], [11]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[10], [11]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[10], [11]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[10], [11]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[10], [11]

References
1	Product Information. Resonium Calcium (calcium polystyrene sulfonate). Sanofi-Synthelabo Canada Inc, Markham, ON.
2	Ziessman HA "Alkalosis and seizure due to a cation-exchange resin and magnesium hydroxide." South Med J 69 (1976): 497-9.[PMID: 817399]
3	Madias NE, Levey AS "Metabolic alkalosis due to absorption of "nonabsorbable" antacids." Am J Med 74 (1983): 155-8.[PMID: 6849324]
4	Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]
5	Product Information. Amiodarone Hydrochloride (amiodarone). Bedford Laboratories, Bedford, OH.
6	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
7	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
8	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
9	Canadian Pharmacists Association.
10	Cerner Multum, Inc. "Australian Product Information.".
11	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
12	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
13	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
14	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
15	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
16	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
17	Morris GC, Egan JG, Jones MK "Hypokalaemic paralysis induced by bolus prednisolone in Graves' disease." Aust N Z J Med 22 (1992): 312. [PMID: 1497563]
18	Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5. [PMID: 6698408]
19	Product Information. Hydeltrasol (prednisolone). Merck &amp Co, Inc, West Point, PA.
20	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
21	Multum Information Services, Inc. Expert Review Panel.
22	McLean M, Kirkwood I, Epstein M, Jones B, Hall C "Cation-exchange resin and inhibition of intestinal absorption of thyroxine." Lancet 34 (1993): 1286. [PMID: 8098431]
23	Product Information. Kayexalate (sodium polystyrene sulfonate). Sanofi Winthrop Pharmaceuticals, New York, NY.
24	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.

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