Drug General Information (ID: DDIECXWGAV)
Drug Name			Thyroid, porcine		Drug Info		Patiromer		Drug Info
Drug Type		Hormones				Small molecule
Therapeutic Class		Thyroid Drugs				Cation Exchange Resins

Mechanism of Thyroid, porcine-Patiromer Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Thyroid, porcine				Patiromer
Mechanism		Binds to cation exchange resin/polymer				Cation exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Patiromer due to formation of complexes caused by Thyroid, porcine

Recommended Action
Management		Thyroid hormone preparations and ion-exchange resins should be administered at least 4 hours apart. Close clinical and laboratory monitoring of thyroid function is recommended during coadministration, since adjusting the dosing interval may not completely prevent the interaction.

References
1	McLean M, Kirkwood I, Epstein M, Jones B, Hall C "Cation-exchange resin and inhibition of intestinal absorption of thyroxine." Lancet 34 (1993): 1286. [PMID: 8098431]
2	Product Information. Kayexalate (sodium polystyrene sulfonate). Sanofi Winthrop Pharmaceuticals, New York, NY.
3	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.