Drug General Information (ID: DDIT743SU2)
  Drug Name Calcipotriol (topical) Drug Info Abaloparatide Drug Info
  Drug Type Small molecule Hormones
  Therapeutic Class Antipsoriatic Agents Hormone Modulators
  Structure

 Mechanism of Calcipotriol (topical)-Abaloparatide Interaction (Severity Level: Moderate)
     Increased risk of hypercalcemia Click to Show/Hide Mechanism Graph
      Drug Name Calcipotriol (topical) Abaloparatide
      Mechanism Hypercalcemia Hypercalcemia
      Key Mechanism Factor 1
Factor Name Hypercalcemia
Factor Description Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work.
      Mechanism Description
  • Increased risk of hypercalcemia by the combination of Calcipotriol (topical) and Abaloparatide 

Recommended Action
      Management Calcium and vitamin D status should be monitored closely when topical vitamin D analogs are used in combination with systemic vitamin D products or other agents that can increase serum calcium levels.

References
1 Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
2 Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.