Drug General Information (ID: DDIPLM1Y87)
Drug Name			Kaolin		Drug Info		Lincomycin		Drug Info
Drug Type		Natural product				Small molecule
Therapeutic Class		Herbal Products				Antibiotics
Structure

Mechanism of Kaolin-Lincomycin Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Kaolin				Lincomycin
Mechanism		Adsorbent antidiarrheal agents				Adsorbed by adsorbent antidiarrheal agents
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Lincomycin due to adsorption of Kaolin

Recommended Action
Management		The use of adsorbent antidiarrheals should be avoided if possible. If used concurrently, the patient should be monitored closely for loss of antibiotic efficacy.

References
1	Albert KS, DeSante KA, Welch RD, DiSanto AR "Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin." J Pharm Sci 67 (1978): 1579-82. [PMID: 712595]
2	McCall CE, Steigbigel NH, Finland M "Lincomycin: activity in vitro and absorption and excretion in normal young men." Am J Med Sci 254 (1967): 144-55. [PMID: 4951792]
3	McGehee RF Jr, Smith CB, Wilcox C, Finland M "Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin." Am J Med Sci 256 (1968): 279-92. [PMID: 4386950]
4	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
5	Product Information. Lincocin (lincomycin). Pharmacia and Upjohn, Kalamazoo, MI.