Details of Drug

Details of Drug

 Drug General Information (ID: D0931)
  Drug Name
Lincomycin
  Drug Type Small molecule
  Drug Synonymous
Cillimycin; Epilincomycin; Jiemycin; LCM; Lincocin; Lincocine; Lincolcina; Lincolnensin; Lincomicina; Lincomix; Lincomycine; Lincomycinum; Lincomyocin; Lincorex; Mycivin; Lincomycin A; Lincomycine [French]; CBMicro_021584; Lincomix 20; Pura Ject 100; Lincocin (TN); Lincomicina [INN-Spanish]; Lincomycine [INN-French]; Lincomycinum [INN-Latin]; U 10,149A; Lincomycin (USAN/INN); Lincomycin [USAN:INN:BAN]; Lincomycin, (2S-cis)-Isomer; Methyl 6,8-dideoxy-6-[(1-methyl-4-propylprolyl)amino]-1-thiooctopyranoside
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  Disease Class 1B74-1F40: Gram-positive bacterial infection
  Therapeutic Class Antibiotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C18H34N2O6S
  InChI 1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1
  InChIKey OJMMVQQUTAEWLP-KIDUDLJLSA-N
  Canonical SMILES CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O
  External Link
Pubchem ID 3000540
CAS Number 154-21-2
CHEBI ID 6472
TTD ID D0Q0EX

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM002  Altered intestinal flora
BM004  Adsorption
BM014  Interference of cell/tissue uptake
BM045  Additive neuromuscular blocking effects
BM100  Antagonize the effect of vaccine/toxoid
BM104  Competitive binding of the 50S ribosomal subunit
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Lincomycin
      Affected gastrointestinal absorption
   Altered intestinal flora Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Moderate    Inter Info   
[29], [30]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Moderate    Inter Info   
[29], [30]
   Adsorption Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0125
 
Attapulgite
 
Al2H29Mg2O15Si4-
 
56842194 
Moderate    Inter Info   
[5], [6], [7], [8], [9]
D0877
 
Kaolin
 
Al2H4O9Si2
 
56841936 
Moderate    Inter Info   
[5], [6], [7], [8], [9]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[25]
      Pharmacodynamic additive effects
   Additive neuromuscular blocking effects Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0343
 
Cisatracurium
 
C53H72N2O12+2
 
62887 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D0122
 
Atracurium
 
C53H72N2O12+2
 
47319 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1384
 
Rapacuronium
 
C37H61N2O4+
 
5311399 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1047
 
Metocurine
 
C40H48N2O6+2
 
21233 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1080
 
Mivacurium
 
C58H80N2O14+2
 
5281042 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1219
 
Pancuronium
 
C35H60N2O4+2
 
441289 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1295
 
Pipecuronium
 
C35H62N4O4+2
 
50192 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1420
 
Rocuronium
 
C32H53N2O4+
 
441290 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1510
 
Succinylcholine
 
C14H30N2O4+2
 
5314 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1659
 
Tubocurarine
 
C37H41N2O6+
 
6000 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
D1684
 
Vecuronium
 
C34H57N2O4+
 
39765 
Moderate    Inter Info   
[11], [12], [13], [14], [15], [1], [16], [17], [18], [8], [19], [9], [20]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[4]
   Competitive binding of the 50S ribosomal subunit Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[21], [8]
   Attenuated pharmacological effects (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0145
 
Balsalazide
 
C17H15N3O6
 
54585 
Moderate    Inter Info   
[10]
D0606
 
Estradiol
 
C18H24O2
 
5757 
Moderate    Inter Info   
[22], [23], [24]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[22], [23], [24]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[26], [27], [28]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[22], [23], [24]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 UK government "Typhoid.".
3 American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
4 Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
5 Albert KS, DeSante KA, Welch RD, DiSanto AR "Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin." J Pharm Sci 67 (1978): 1579-82. [PMID: 712595]
6 McCall CE, Steigbigel NH, Finland M "Lincomycin: activity in vitro and absorption and excretion in normal young men." Am J Med Sci 254 (1967): 144-55. [PMID: 4951792]
7 McGehee RF Jr, Smith CB, Wilcox C, Finland M "Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin." Am J Med Sci 256 (1968): 279-92. [PMID: 4386950]
8 Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
9 Product Information. Lincocin (lincomycin). Pharmacia and Upjohn, Kalamazoo, MI.
10 Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.
11 Alahdal O, Bevan DR "Clindamycin-induced neuromuscular blockade." Can J Anaesth 42 (1995): 614-7. [PMID: 7553999]
12 Avery D, Finn R "Succinylcholine-prolonged apnea associated with clindamycin and abnormal liver function tests." Dis Nerv Syst 38 (1977): 473-5. [PMID: 862507]
13 Boolj LH, Miller RD, Crul JF "Neostigmine and 4-aminopyridine antagonism of lincomycin-pancuronium neuromuscular blockade in man." Anesth Analg 57 (1978): 316-21. [PMID: 566050]
14 Canadian Pharmacists Association.
15 Cerner Multum, Inc. "Australian Product Information.".
16 de Gouw NE, Crul JF, Vandermeersch E, Mulier JP, van Egmond J, Van Aken H "Interaction of antibiotics on pipecuronium-induced neuromuscular blockade." J Clin Anesth 5 (1993): 212-5. [PMID: 8391282]
17 Fogdall RP, Miller RD "Antagonism of d-tubocurarine- and pancuronium-induced neuromuscular blockades by pyridostigmine in man." Anesthesiology 39 (1973): 504-9. [PMID: 4355635]
18 Jedeikin R, Dolgunski E, Kaplan R, Hoffman S "Prolongation of neuromuscular blocking effect of vecuronium by antibiotics." Anaesthesia 42 (1987): 858-60. [PMID: 2889390]
19 Product Information. Clindesse (clindamycin topical). Ther-Rx Corporation, Bridgeton, MO.
20 Rubbo JT, Gergis SD, Sokoll MD "Comparative neuromuscular effects of lincomycin and clindamycin." Anesth Analg 56 (1977): 329-32. [PMID: 194504]
21 Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
22 Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
23 Barnett ML "Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration." J Periodontol 56 (1985): 18-20. [PMID: 3882930]
24 King VJ "OC failure rates and oral antibiotics." J Fam Pract 45 (1997): 104-5. [PMID: 9267366]
25 Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
26 Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
27 MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
28 Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
29 Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
30 Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.