Drug General Information (ID: DDID6GNX9Z)
Drug Name			Lincomycin		Drug Info		Indium In-111 oxyquinoline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Lincomycin-Indium In-111 oxyquinoline Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Lincomycin				Indium In-111 oxyquinoline
Mechanism		Cause false-negative results with Indium In-111-labeled leukocyte studies				Indium In-111 oxyquinoline
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Indium In-111 oxyquinoline by Lincomycin

Recommended Action
Management		Clinicians should be aware of possible diagnostic interference in patients who are on long-term antibiotic treatment, corticosteroids, interleukin-2, parenteral nutrition, or high doses or supratherapeutic concentrations of lidocaine or procainamide.

References
1	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.