Drug General Information (ID: DDINJGH6BK)
Drug Name			Ethanol		Drug Info		Metamfetamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Cns Stimulants
Structure

Mechanism of Ethanol-Metamfetamine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Metamfetamine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Ethanol and Metamfetamine

Recommended Action
Management		Concomitant use of centrally-acting appetite suppressants and alcohol should be avoided if possible, especially in patients with a history of cardiovascular disease. Patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References
1	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
2	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
3	Product Information. Suprenza (phentermine). Akrimax Pharmaceuticals, Cranford, NJ.