Details of Drug

Drug General Information (ID: D1012)
Drug Name	Metamfetamine
Drug Type	Small molecule
Drug Synonymous	METHAMPHETAMINE; Metamfetamine; d-Deoxyephedrine; d-Desoxyephedrine; d-Methamphetamine; d-N-Methylamphetamine; Metamphetamine; L-Methamphetamine; d-Methylamphetamine; Methylamphetamine; d-Phenylisopropylmethylamine; N-Methylamphetamine; (S)-Methamphetamine; Norodin; (+)-Methylamphetamine; d-(S)-Methamphetamine; D-1-Phenyl-2-methylaminopropane; Metamfetaminum; Desyphed; (+)-N-Methylamphetamine; (S)-Methylamphetamine; (+)-(S)-Deoxyephedrine; Methyl-beta-phenylisopropylamine; 1-Phenyl-2-methylaminopropane; (S)-(+)-Deoxyephedrine; Crank; Desohyephedrine; Metamfetamina; Meth; Methamphetaminum; Speed; Stimulex; Crank [Street Name]; Crystal Meth; Crystal Meth [Street Name]; Desyphed hydrochloride; ICE [Street Name]; Metamfetamine [INN];Metamfetaminum [Latin]; Metanfetamina [Spanish]; Methamphetaminum [JP]; Speed [Street Name]; D-Deoxyephedrine; D-Desoxyephedrine; D-Methamphetamine; D-Methylamphetamine; D-Phenylisopropylmethylamine;Desoxyn (TN); Metamfetamina [INN-Spanish]; Metamfetamine (INN); Metamfetamine-m; Metamfetaminum [INN-Latin]; Metanfetamina [INN-Spanish]; Meth (Street Name); Methamphetaminum [INN-Latin]; D-N-Methylamphetamine; D-(S)-Methamphetamine; D-N,alpha-dimethylphenethylamine; Methamphetamine, its salts, isomers, and salts of its isomers; N-Methyl-beta-phenylisopropylamin; N-Methyl-beta-phenylisopropylamin [German]; N-Methyl-beta-phenylisopropylamine; D-1-Phenyl-2-methylaminopropan; D-1-Phenyl-2-methylaminopropan [German]; S-(+)-Methamphetamine; D-N,alpha-Dimethylphenethylamine; N-Methyl-1-phenyl-2-propanamine; Benzeneethanamine, N,alpha-dimethyl-, (S)-(9CI); Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-(9CI); Phenethylamine, N,alpha-dimethyl-, (S)-(+)-(8CI); (+)-(S)-N-alpha-Dimethylphenethylamine; (+)-2-(N-Methylamino)-1-phenylpropane; (+)-N,alpha-Dimethyl-beta-phenylethylamine; (+)-N,alpha-Dimethylphenethylamine; (+)-methamphetamine; (2S)-N-methyl-1-phenylpropan-2-amine; (S)-(+)-Methamphetamine; (S)-(+)-N,alpha,dimethylphenethylamine; (S)-N,alpha-Dimethylbenzeneethanamine; (S)-N,alpha-Dimethylbenzeneethanoamine; (alphaS)-N,alpha-dimethylbenzeneethanamine; 1-Phenyl-2-methylamino-propan; 1-Phenyl-2-methylamino-propan [German]; 2S-(+)-Methamphetamine; Methamfetamine Click to Show/Hide
Disease Class	MG30-MG3Z: Pain; 6A05: Attention deficit hyperactivity disorder
Therapeutic Class	Cns Stimulants
Structure
Structure	3D Structure		2D Structure
Formula	C10H15N
InChI	1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1
InChIKey	MYWUZJCMWCOHBA-VIFPVBQESA-N
Canonical SMILES	CC(CC1=CC=CC=C1)NC
External Link
	Pubchem ID	10836
	CAS Number	537-46-2
	CHEBI ID	6809
	TTD ID	D0P6UB
	INTEDE ID	DR1036
	VARIDT ID	DR00256

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM005 Altered gastric pH BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM029 Altered urine pH BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM046 Additive serotonergic effects BM061 Increased risk of hyperpyrexia BM064 Increased risk of hypoglycemia BM069 Increased risk of lowers seizure threshold BM078 Increased risk of rapid heart rate BM083 Potentiated the pharmacological effects (Unspecific) BM089 Antagonize the effect of antihypertensive agents BM093 Antagonize the effect of dopaminergic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Metamfetamine
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0111		Ascorbic acid	C6H8O6	54670067	Moderate		Inter Info	[37], [38], [26]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[37], [18], [26]
D0729		Glutamic acid	C5H9NO4	33032	Moderate		Inter Info	[37], [38], [26]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[37], [18], [26]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[37], [18], [26]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[37], [18], [26]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[37], [18], [26]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[37], [18], [26]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[37], [18], [26]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[20]
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[46], [43], [85]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[4], [5], [6]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[39]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[40], [41], [42]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[43], [44], [45]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[46], [47], [43]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[37], [26], [48]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[40], [10], [57]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[43], [65], [66]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[71]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[72], [73], [74]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[75]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[76], [77]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[40], [10], [79]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[80], [81], [82]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[83]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[10], [84]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[89]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[90], [66]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[40], [10], [94]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[43], [97], [66]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[101]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[103]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[106], [107]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[108], [109], [110]
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[98], [99], [100]
Affected excretion pathways
	Altered urine pH					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0070		Ammonium chloride	ClH4N	25517	Moderate		Inter Info	[69], [38], [70]
D0886		Lactic acid	C3H6O3	612	Moderate		Inter Info	[86], [87], [88]
D1020		Methenamine	C6H12N4	4101	Moderate		Inter Info	[69], [38], [70]
D1086		Monopotassium phosphate	H2KO4P	516951	Moderate		Inter Info	[69], [38], [70]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[86], [87], [88]
D1478		Sodium acetate	C2H3NaO2	517045	Moderate		Inter Info	[86], [87], [88]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[86], [87], [88]
D1654		Tromethamine	C4H11NO3	6503	Moderate		Inter Info	[86], [87], [88]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[86], [87], [88]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[37], [26], [28]
	Additive hypertensive effects					Drug Num: 49
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[7], [8], [9]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[10], [11], [12]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[10], [11], [12]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[7], [8], [9]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[7], [8], [9]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[7], [8], [9]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[7], [8], [9]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[7], [8], [9]
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[19]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[7], [8], [9]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[7], [8], [9]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[7], [8], [9]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[7], [8], [9]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[7], [8], [9]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[7], [8], [9]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[7], [8], [9]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[7], [8], [9]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[7], [8], [9]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[34], [35], [36]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[34], [35], [36]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[34], [35], [36]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[34], [35], [36]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[34], [35], [36]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[34], [35], [36]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[34], [35], [36]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[34], [35], [36]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[40], [10], [58]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[34], [35], [36]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[78]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[34], [35], [36]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[34], [35], [36]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[34], [35], [36]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[34], [35], [36]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[34], [35], [36]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[34], [35], [36]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[34], [35], [36]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[34], [35], [36]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[34], [35], [36]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[10], [102]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[34], [35], [36]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[34], [35], [36]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[34], [35], [36]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[34], [35], [36]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[34], [35], [36]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[99], [104], [105]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[34], [35], [36]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[34], [35], [36]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[34], [35], [36]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[34], [35], [36]
	Additive serotonergic effects					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[29], [30], [31]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[29], [30], [31]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[29], [30], [31]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[29], [30], [31]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[29], [30], [31]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[29], [30], [31]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[29], [30], [31]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[29], [30], [31]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[29], [30], [31]
	Increased risk of hyperpyrexia					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[16], [17], [18]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[16], [17], [18]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[16], [17], [18]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[16], [17], [18]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[16], [17], [18]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[16], [17], [18]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[91], [92], [93]
	Increased risk of hypoglycemia					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[26], [27], [28]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[26], [27], [28]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[26], [27], [28]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[26], [27], [28]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[26], [27], [28]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[26], [27], [28]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[26], [27], [28]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[26], [27], [28]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[26], [27], [28]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[26], [27], [28]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [27], [28]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [27], [28]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [27], [28]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [27], [28]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [27], [28]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [27], [28]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[26], [27], [28]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[26], [27], [28]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[26], [27], [28]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[26], [27], [28]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[26], [27], [28]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[26], [27], [28]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[26], [27], [28]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[26], [27], [28]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[26], [27], [28]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[26], [27], [28]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[26], [27], [28]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[26], [27], [28]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[26], [27], [28]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[26], [27], [28]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[26], [27], [28]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[26], [27], [28]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[26], [27], [28]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[26], [27], [28]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[26], [27], [28]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[26], [27], [28]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[26], [27], [28]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[26], [27], [28]
	Increased risk of lowers seizure threshold					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[13], [14], [15]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[13], [14], [15]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[23], [24], [25]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[52], [53], [54]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[62], [63], [64]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[67], [68]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[95], [96], [10]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[95], [96], [10]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[95], [96], [10]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[59], [60], [61]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[59], [60], [61]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[59], [60], [61]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0165		Benzphetamine	C17H21N	5311017	Major		Inter Info	[1], [2], [3]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[1], [2], [3]
D0486		Diethylpropion	C13H19NO	7029	Major		Inter Info	[1], [2], [3]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[1], [2], [3]
D0981		Mazindol	C16H13ClN2O	4020	Major		Inter Info	[1], [2], [3]
D0952		Lorcaserin	C11H14ClN	11658860	Major		Inter Info	[1], [2], [3]
D1262		Phendimetrazine	C12H17NO	30487	Major		Inter Info	[1], [2], [3]
D1270		Phentermine	C10H15N	4771	Major		Inter Info	[1], [2], [3]
D1281		Phenylpropanolamine	C9H13NO	26934	Major		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[49], [50], [51]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[49], [50], [51]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[49], [50], [51]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[49], [50], [51]
	Antagonize the effect of dopaminergic agents					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[21], [22]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[32], [17], [33]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[32], [17], [33]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[32], [17], [33]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[32], [55], [56]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[32], [17], [33]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[32], [17], [33]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[32], [17], [33]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[32], [17], [33]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[32], [17], [33]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[32], [17], [33]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[32], [17], [33]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[32], [17], [33]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[32], [17], [33]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[32], [17], [33]

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