Details of Drug-Drug Interaction
| Drug General Information (ID: DDI7SORQT1) | |||||||||
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| Drug Name | Alfentanil | Drug Info | Metamfetamine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Anesthetics | Cns Stimulants | |||||||
| Structure | |||||||||
| Mechanism of Alfentanil-Metamfetamine Interaction (Severity Level: Moderate) | |||||||||
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| Additive serotonergic effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Alfentanil | Metamfetamine | |||||||
| Mechanism | Serotonergic effects | Serotonergic effects | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Serotonergic effects | ||||||||
| Factor Description | Serotonergic drugs include a variety of drugs that enhance or mimic the effects of the neurotransmitter serotonin. Excessive serotonergic activation may lead to a condition known as serotonin syndrome, in which high levels of serotonin in the brain cause the following symptoms: changes in blood pressure, coma, fever, increased heart rate, hallucinations, nausea, and seizures. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is recommended when amphetamines and amphetamine-like drugs are used with dextromethorphan or opioids with serotonergic effects such as fentanyl, meperidine, methadone, propoxyphene, and tramadol. Patients should be monitored for symptoms of the serotonin syndrome during treatment. Particular caution is advised when increasing the dosages of these agents. If serotonin syndrome develops or is suspected during the course of therapy, all serotonergic agents should be discontinued immediately and supportive care rendered as necessary. Moderately ill patients may also benefit from the administration of a serotonin antagonist (e.g., cyproheptadine, chlorpromazine). Severe cases should be managed under consultation with a toxicologist and may require sedation, neuromuscular paralysis, intubation, and mechanical ventilation in addition to the other measures. | ||||||||