Drug General Information (ID: DDILOM86ES)
Drug Name			Dapsone		Drug Info		Aminolevulinic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Malignancy Photosensitizers
Structure

Mechanism of Dapsone-Aminolevulinic acid Interaction (Severity Level: Major)
Increased risk of photosensitivity reactions Click to Show/Hide Mechanism Graph
Drug Name		Dapsone				Aminolevulinic acid
Mechanism		Photosensitivity reactions				Photosensitivity reactions
Key Mechanism Factor 1
		Factor Name		Photosensitivity reactions
		Factor Description		Drug-induced photosensitivity reactions occur when certain photosensitizing drugs cause unexpected sunburn or dermatitis (dry, bumpy or blistering rash) on sun-exposed skin (face, neck, arms, backs of hands, and often lower legs and feet). The rash may or may not be itchy.
Mechanism Description		Increased risk of photosensitivity reactions by the combination of Dapsone and Aminolevulinic acid

Recommended Action
Management		Photosensitizing agents (e.g., fluoroquinolones, phenothiazines, retinoids, sulfonamides, sulfonylureas, tetracyclines, thiazide diuretics, griseofulvin, St. John's wort) and topical preparations containing aminolevulinic acid should generally not be administered for 24 hours before and after oral administration of aminolevulinic acid.

References
1	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2	Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.