Details of Drug-Drug Interaction
| Drug General Information (ID: DDIK06F8NP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Paricalcitol | Drug Info | Aluminum hydroxide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Parasympathomimetics | Antacids | |||||||
| Structure | |||||||||
| Mechanism of Paricalcitol-Aluminum hydroxide Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Paricalcitol | Aluminum hydroxide | |||||||
| Mechanism | Increase absorption of aluminum | Aluminum-containing products | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetic | ||||||||
| Factor Description | Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Aluminum-containing preparations (e.g., antacids, phosphate binders) should not be administered chronically with vitamin D analogs. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cerner Multum, Inc. "UK Summary of Product Characteristics.". | ||||||||||||||||||
| 2 | Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL. | ||||||||||||||||||