Details of Drug

Drug General Information (ID: D1226)
Drug Name	Paricalcitol
Drug Type	Small molecule
Drug Synonymous	Paracalcin; Zemplar; Abbott brand of paricalcitol; Paricalcitol [USAN]; Ab 122358; ABT-358; Zemplar (TN); Paricalcitol (USAN/INN); Paricalcitol, 19-nor-(OH)2-vitD2, paracalcin; (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol; (1R,3R,7E)-17beta-[(2R,3E,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-9,10-secoestra-5,7-diene-1,3-diol; (1alpha.3beta,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol; (7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1alpha,3beta,25-triol; 19-Nor-1,25-(OH)2D2; 19-Nor-1-alpha,25-dihydroxyvitamin D2; 19-Nor-1alpha,25-dihydroxyvitamin D2; 19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol,(1alpha,3beta,7E,22E) Click to Show/Hide
Disease Class	5A51: Hyper-parathyroidism
Therapeutic Class	Parasympathomimetics
Structure
Structure	3D Structure		2D Structure
Formula	C27H44O3
InChI	1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1
InChIKey	BPKAHTKRCLCHEA-UBFJEZKGSA-N
Canonical SMILES	CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3)O)O)C
External Link
	Pubchem ID	5281104
	CAS Number	131918-61-1
	CHEBI ID	7931
	TTD ID	D0N1TP

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM004 Adsorption BM008 Altered Fat-soluble drugs absorption BM009 Altered absorption (Unspecific) BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM059 Increased risk of hypermagnesemia BM107 Attenuated pharmacological effects (Unspecific) BM108 Increased risk of hypercalcemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Paricalcitol
Affected gastrointestinal absorption
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0850		Iron sucrose	C12H29Fe5Na2O23	91663255	Moderate		Inter Info	[33]
	Altered Fat-soluble drugs absorption					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[13], [1], [14], [15], [10], [16]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[13], [1], [14], [15], [10], [16]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[13], [1], [14], [15], [10], [16]
D1462		Sevelamer	C6H12ClNO	3085017	Moderate		Inter Info	[13], [1], [14], [15], [10], [16]
	Altered absorption (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Major		Inter Info	[1], [4]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Major		Inter Info	[1], [4]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[30], [31], [32]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1], [4]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1], [4]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1], [4]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[1], [4]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[19]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[1], [4]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[21]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[1], [4]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1], [4]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1], [4]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[24]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1], [28]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1], [4]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[29]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[1], [4]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1], [4]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1], [4]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[13], [1], [34]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[35]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[1], [4]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1], [4]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1], [4]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1], [4]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[47]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[48], [31]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1], [4]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1], [4]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[1], [4]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[1], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1], [4]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1], [4]
	CYP450 enzyme induction					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[2], [3], [10], [4]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[2], [3], [10], [4]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[2], [3], [10], [4]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[2], [10], [4]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[13], [1], [17], [18]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[2], [3], [10], [4]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[2], [3], [10], [4]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[1], [20]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [22]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[13], [25]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[26], [13], [1], [27]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[2], [3], [10], [4]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[2], [3], [10], [4]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[2], [3], [10], [4]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[36]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[37]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[2], [3], [10], [4]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[2], [10], [4]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[2], [3], [10], [4]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[2], [3], [10], [4]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[13], [1], [49]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[13], [1], [50], [49]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [51]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[2], [3], [10], [4]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[2], [3], [10], [4]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[2], [3], [10], [4]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[2], [3], [10], [4]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[13], [1], [49]
Pharmacodynamic additive effects
	Increased risk of hypermagnesemia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[2], [3], [10], [4]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[2], [3], [10], [4]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[2], [3], [10], [4]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[2], [3], [10], [4]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[2], [3], [10], [4]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Moderate		Inter Info	[2], [3], [10], [4]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[2], [3], [10], [4]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[2], [3], [10], [4]
	Increased risk of hypercalcemia					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0233		Calcifediol	C27H44O2	5283731	Major		Inter Info	[1], [2], [3]
D0234		Calcitriol	C27H44O3	5280453	Major		Inter Info	[1], [2], [3]
D0328		Cholecalciferol	C27H44O	5280795	Major		Inter Info	[1], [2], [3]
D0591		Ergocalciferol	C28H44O	5280793	Major		Inter Info	[1], [2], [3]
D0495		Dihydrotachysterol	C28H46O	5311071	Major		Inter Info	[1], [2], [3]
D0527		Doxercalciferol	C28H44O2	5281107	Major		Inter Info	[1], [2], [3]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[7], [8], [9]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[7], [8], [9]
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[11], [12]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[7], [8], [9]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[7], [8], [9]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[7], [8], [9]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[7], [8], [9]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[7], [8], [9]
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[11], [12]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[7], [8], [9]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[7], [8], [9]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[7], [8], [9]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0221		Burosumab	NA	NA	Major		Inter Info	[5]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[1], [4], [23]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[6]

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