Drug General Information (ID: DDIHI8M63L)
Drug Name			Ethionamide		Drug Info		Ethanol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antituberculosis Agents				Analgesics
Structure

Mechanism of Ethionamide-Ethanol Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Ethionamide				Ethanol
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Ethionamide and Ethanol

Recommended Action
Management		Consumption of alcohol during protionamide treatment should be avoided. The manufacturer of ethionamide also advises that excess alcohol consumption should be avoided during ethionamide therapy (US).

References
1	World Health Organization "WHO Public Assessment Reports (WHOPARs).".
2	Product Information. Trecator-SC (ethionamide). Wyeth-Ayerst Laboratories, Philadelphia, PA.