Details of Drug

Drug General Information (ID: D1731)
Drug Name	Ethionamide
Drug Type	Small molecule
Drug Synonymous	Aethionamidum; Aetina; Aetiva; Amidazin; Amidazine; Atina; Ethatyl; Ethimide; Ethina; Ethinamide; Ethionamidum; Ethioniamide; Ethylisothiamide; Ethyonomide; Etimid; Etiocidan; Etionamid; Etionamida; Etionamide; Etioniamid; Etionid; Etionizin; Etionizina; Etionizine; Fatoliamid; Iridocin; Iridozin; Isothin; Isotiamida; Itiocide; Nicotion; Nisotin; Nizotin; Rigenicid; Sertinon; Teberus; Thianid; Thianide; Thioamide; Thiomid; Thioniden; Tianid; Tiomid; Trecator; Trekator; Trescatyl; Trescazide; Tubenamide; Tubermin; Tuberoid; Tuberoson; Ethionamid prothionamid; Etionamide [DCIT]; Iridocin Bayer; Trecator SC; Wyeth Brand of Ethionamide; Bayer 5312; Bayer5312; E0695; TH 1314; Alpha-Ethylisonicotinic acid thioamide; Alpha-Ethylisonicotinoylthioamide; Alpha-Ethylisothionicotinamide; Alpha-Ethylthioisonicotinamide; Alpha-ethylt hioisonicotinamide; Ethina (VAN); Ethionamidum [INN-Latin]; Etionamida [INN-Spanish]; Tio-Mid; Trecator-SC; Alpha-Ethyl-thioisonicotinamide; Trecator-SC (TN); Ethionamide (JP15/USP/INN); Ethionamide [USAN:INN:BAN:JAN]; 2-ETHYL-4-PYRIDINECARBOTHIOAMIDE; 2-Ethyl-4-thioamidylpyridine; 2-Ethyl-4-thiocarbamoylpyridine; 2-Ethyl-thioisonicotinamide; 2-Ethylisonicotinic acid thioamide; 2-Ethylisonicotinic thioamide; 2-Ethylisonicotinothioamide; 2-Ethylisonicotinoylthioamide; 2-Ethylisothionicotinamide; 2-Ethylthioisonicotinamide; 2-e thylisothionicotinamide; 2-ethyl-4-aminothiocarbonylpyridine; 2-ethylisonicotinic acid thiomide; 2-ethylpyridine-4-carbothioamide; 2-ethylthioisonicotinamide, Trecator SC, Amidazine, Ethionamide; 3-Ethylisothionicotinamide Click to Show/Hide
Disease Class	1B10-1B14: HIV-infected patients with tuberculosis
Therapeutic Class	Antituberculosis Agents
Structure
Structure	3D Structure		2D Structure
Formula	C8H10N2S
InChI	1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
InChIKey	AEOCXXJPGCBFJA-UHFFFAOYSA-N
Canonical SMILES	CCC1=NC=CC(=C1)C(=S)N
External Link
	Pubchem ID	2761171
	CAS Number	536-33-4
	CHEBI ID	4885
	TTD ID	D0O5ZK
	INTEDE ID	DR1752

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM038 Additive CNS depression effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ethionamide
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[142]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0617		Ethanol	C2H6O	702	Major		Inter Info	[1], [2]
	Increased risk of hepatotoxicity					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[3], [4], [5]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[6]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[8]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[9], [10], [11]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[3], [4], [5]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[119], [120], [121], [9], [12], [122], [123], [124], [125], [126], [127], [128], [129]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[9], [12], [133]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[119], [120], [121], [9], [12], [122], [123], [124], [125], [126], [127], [128], [129]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[134]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[135], [136]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[119], [120], [121], [9], [12], [122], [123], [124], [125], [126], [127], [128], [129]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[12], [137]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[138]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[139], [140]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[141]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[150]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[151], [152], [153], [154]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[9], [12], [158], [159], [160]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[12], [162]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[151], [152], [153], [154]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[151], [152], [153], [154]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[12], [164]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[119], [120], [121], [9], [12], [122], [123], [124], [125], [126], [127], [128], [129]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[165], [166]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[23], [80], [97]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[23], [80], [97]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [143], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [144], [80], [145], [146], [85], [147], [148], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [149], [112], [113], [1], [115]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [143], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [144], [80], [145], [146], [85], [147], [148], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [149], [112], [113], [1], [115]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [143], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [144], [80], [145], [146], [85], [147], [148], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [149], [112], [113], [1], [115]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [1], [115]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [143], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [144], [80], [145], [146], [85], [147], [148], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [149], [112], [113], [1], [115]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [143], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [144], [80], [145], [146], [85], [147], [148], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [149], [112], [113], [1], [115]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[23], [80], [97]
	Increased risk of peripheral neuropathy					Drug Num: 74
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[130], [131], [132]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[116], [117], [118]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[116], [117], [118]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[116], [117], [118]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[116], [117], [118]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[116], [117], [118]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[116], [117], [118]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[116], [117], [118]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[116], [117], [118]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[116], [117], [118]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[116], [117], [118]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[116], [117], [118]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[116], [117], [118]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[116], [117], [118]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[116], [117], [118]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[116], [117], [118]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[116], [117], [118]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[116], [117], [118]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[116], [117], [118]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[116], [117], [118]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[116], [117], [118]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[116], [117], [118]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[116], [117], [118]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[116], [117], [118]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[116], [117], [118]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[116], [117], [118]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[116], [117], [118]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[116], [117], [118]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[116], [117], [118]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[116], [117], [118]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[116], [117], [118]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[116], [117], [118]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[116], [117], [118]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[116], [117], [118]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[116], [117], [118]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[116], [117], [118]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[116], [117], [118]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[116], [117], [118]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[116], [117], [118]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[116], [117], [118]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[116], [117], [118]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[116], [117], [118]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[116], [117], [118]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[116], [117], [118]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[116], [117], [118]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[116], [117], [118]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[116], [117], [118]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[130], [9], [12], [161]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[116], [117], [118]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[116], [117], [118]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[130], [163]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[116], [117], [118]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[116], [117], [118]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[116], [117], [118]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[116], [117], [118]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[116], [117], [118]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[116], [117], [118]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[116], [117], [118]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[116], [117], [118]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[116], [117], [118]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[116], [117], [118]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[116], [117], [118]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[116], [117], [118]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[12], [13], [14]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[15]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[155], [156], [157]

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125	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
126	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
127	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
128	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
129	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
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132	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
133	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
134	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
135	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
136	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
137	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
138	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
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140	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
141	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
142	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
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144	Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
145	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
146	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
147	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
148	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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150	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
151	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
152	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
153	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
154	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
155	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
156	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
157	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
158	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
159	Gilead Sciences, Inc "About Remdesivir.".
160	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
161	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
162	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
163	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
164	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
165	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
166	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.

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