Drug General Information (ID: DDIGUZN457)
Drug Name			Lorcaserin		Drug Info		Avanafil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anorexiants				Impotence Agents
Structure

Mechanism of Lorcaserin-Avanafil Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Lorcaserin				Avanafil
Mechanism		Priapism				Priapism
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Lorcaserin and Avanafil

Recommended Action
Management		There is limited experience with the combination of lorcaserin and medications indicated for erectile dysfunction. Caution is advised if coadministration is necessary, particularly in patients with risk factors for priapism such as sickle cell anemia, multiple myeloma, leukemia, or anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, Peyronie's disease). Men who have an erection lasting longer than 4 hours, whether painful or not, should immediately discontinue these drugs and seek emergency medical attention.

References
1	Product Information. Belviq (lorcaserin). Eisai Inc, Teaneck, NJ.