Details of Drug

Drug General Information (ID: D0952)
Drug Name	Lorcaserin
Drug Type	Small molecule
Drug Synonymous	APD 356; APD356; AR-10A; (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine; 10-chloro-2-methyl-4-azabicyclo[5.4.0]undeca-8,10,12-triene Click to Show/Hide
Disease Class	5B80-5B81: Obesity; 6C4G: Psychoactive substances use disorder
Therapeutic Class	Anorexiants
Structure
Structure	3D Structure		2D Structure
Formula	C11H14ClN
InChI	1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
InChIKey	XTTZERNUQAFMOF-QMMMGPOBSA-N
Canonical SMILES	CC1CNCCC2=C1C=C(C=C2)Cl
External Link
	Pubchem ID	11658860
	CAS Number	616202-92-7
	CHEBI ID	65353
	TTD ID	D01JMC
	INTEDE ID	DR0979

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM046 Additive serotonergic effects BM060 Increased risk of hyperprolactinemia BM064 Increased risk of hypoglycemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Lorcaserin
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[8]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[9], [10], [11], [12], [13], [14]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [14], [44], [45], [46], [47], [48], [49], [50], [51]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [14], [62], [63]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[7], [1], [5]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[1]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[1]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[67], [68], [69]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[1]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[70]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[1]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[1]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[71], [72], [73], [74], [75], [76], [14], [77], [78], [79], [80], [81], [82]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[83], [68]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[1]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[1]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[1]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[1]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[1]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[1]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[1]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[7], [1], [5]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[7], [1], [5]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[7], [1], [5]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[1]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[1]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[1]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[1]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[1]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[1]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[1]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[1]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[1]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[1]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[1]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[7], [1], [5]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[1]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[84], [85], [86], [14]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[1]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[7], [1], [5]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[1]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[1]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[87], [88], [89]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[7], [1], [5]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[1]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[90], [14], [91], [92]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[93]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[94], [95], [14]
Pharmacodynamic additive effects
	Additive serotonergic effects					Drug Num: 55
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1]
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[1]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[1]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1]
D0466		Dextromethorphan	C18H25NO	5360696	Major		Inter Info	[1]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[7], [1], [5]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[1]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[1]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[1]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[1]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[1]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[7], [1], [5]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[1]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [1], [5]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[1]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1]
D1200		Oxitriptan	C11H12N2O3	439280	Major		Inter Info	[7], [1], [5]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[1]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[1]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[1]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[15], [16], [17]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[1]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[7], [1], [5]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1]
D1658		Tryptophan	C11H12N2O2	6305	Major		Inter Info	[1]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[1]
	Increased risk of hypoglycemia					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[64], [65], [66]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[64], [65], [66]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[64], [65], [66]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[64], [65], [66]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[64], [65], [66]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[64], [65], [66]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[64], [65], [66]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[64], [65], [66]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[64], [65], [66]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[64], [65], [66]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[64], [65], [66]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[64], [65], [66]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[64], [65], [66]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[64], [65], [66]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[64], [65], [66]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[64], [65], [66]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[64], [65], [66]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[64], [65], [66]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[64], [65], [66]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[64], [65], [66]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[64], [65], [66]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[64], [65], [66]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[64], [65], [66]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[64], [65], [66]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[64], [65], [66]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[64], [65], [66]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[64], [65], [66]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[64], [65], [66]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[64], [65], [66]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[64], [65], [66]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[64], [65], [66]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[64], [65], [66]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[64], [65], [66]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[64], [65], [66]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0165		Benzphetamine	C17H21N	5311017	Major		Inter Info	[2], [3], [4]
D0212		Bromocriptine	C32H40BrN5O5	31101	Major		Inter Info	[1], [5], [6]
D0228		Cabergoline	C26H37N5O2	54746	Major		Inter Info	[1], [5], [6]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[2], [3], [4]
D0486		Diethylpropion	C13H19NO	7029	Major		Inter Info	[2], [3], [4]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [5], [6]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[1], [5], [6]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[1], [5], [6]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[2], [3], [4]
D0981		Mazindol	C16H13ClN2O	4020	Major		Inter Info	[2], [3], [4]
D1012		Metamfetamine	C10H15N	10836	Major		Inter Info	[2], [3], [4]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[1], [5], [6]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[1], [5], [6]
D1255		Pergolide	C19H26N2S	47811	Major		Inter Info	[1], [5], [6]
D1262		Phendimetrazine	C12H17NO	30487	Major		Inter Info	[2], [3], [4]
D1270		Phentermine	C10H15N	4771	Major		Inter Info	[2], [3], [4]
D1281		Phenylpropanolamine	C9H13NO	26934	Major		Inter Info	[2], [3], [4]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[1]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[1]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[1]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[1]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1]
D1713		Yohimbine	C21H26N2O3	8969	Moderate		Inter Info	[1]

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