Drug General Information (ID: DDIGDQYTWO)
Drug Name			Infliximab		Drug Info		Abatacept		Drug Info
Drug Type		Monoclonal antibody				Protein/peptide
Therapeutic Class		Immunosuppressive Agents				Antirheumatics

Mechanism of Infliximab-Abatacept Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Infliximab				Abatacept
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Infliximab and Abatacept

Recommended Action
Management		Concomitant use of abatacept and TNF blockers is not recommended. When transitioning from TNF antagonist therapy to abatacept therapy, patients should be monitored closely for signs of infection such as fever, chills, or sore throat.

References
1	Product Information. Orencia (abatacept). Bristol-Myers Squibb, Princeton, NJ.
2	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.