Details of Drug

Drug General Information (ID: D0004)
Drug Name	Abatacept
Drug Type	Protein/peptide
Drug Synonymous	Orencia (TN) Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis
Therapeutic Class	Antirheumatics
External Link
External Link	TTD ID	D0EW4L

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM043 Additive immunosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Abatacept
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[4], [5], [6]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[7], [8]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[9]
D0736		Golimumab	NA	NA	Major		Inter Info	[7], [8]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[5], [10]
D1447		Sarilumab	NA	NA	Major		Inter Info	[11], [12], [8]
D1448		Satralizumab	NA	NA	Major		Inter Info	[11], [12], [8]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [13]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[17], [18]
D1599		Tocilizumab	NA	NA	Major		Inter Info	[11], [12], [8]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[19]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[5], [20]
D0023		Adalimumab	NA	NA	Major		Inter Info	[7], [8]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[5], [21]
D0614		Etanercept	NA	NA	Major		Inter Info	[7], [8]
D0802		Infliximab	NA	NA	Major		Inter Info	[7], [8]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[5], [17]
D1111		Natalizumab	NA	NA	Major		Inter Info	[22]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[26], [27], [28]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[34]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[35]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[35]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[35]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[36]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[26], [27], [28]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[5], [44]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[45]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[14], [46], [47]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[48]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[26], [27], [28]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[4], [5]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[49]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[1], [2], [3]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[1], [2], [3]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[1], [2], [3]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[1], [2], [3]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[1], [2], [3]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[14], [4], [15]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[16]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[1], [2], [3]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[1], [2], [3]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[1], [2], [3]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[14], [32], [33]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[14], [32], [33]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[14], [32], [33]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[14], [32], [33]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[14], [32], [33]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[14], [32], [33]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[37], [14], [4], [38], [39], [40], [32], [41], [42], [43], [33]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[14], [32], [33]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[14], [32], [33]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[50]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[23], [24], [25]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[23], [24], [25]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[29], [30], [31]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[29], [30], [31]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[51], [52], [53]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[51], [52], [53]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[51], [52], [53]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[51], [52], [53]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[51], [52], [53]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[51], [52], [53]

References
1	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
2	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
3	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
4	Cerner Multum, Inc. "Australian Product Information.".
5	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
7	Product Information. Orencia (abatacept). Bristol-Myers Squibb, Princeton, NJ.
8	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
9	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
10	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
11	Product Information. Kevzara (sarilumab). sanofi-aventis, Bridgewater, NJ.
12	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
13	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
14	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
15	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
16	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
17	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
18	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
19	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
20	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
21	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
22	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
23	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
24	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
25	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
26	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
27	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
28	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
29	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
30	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
31	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
32	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
33	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
34	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
35	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
36	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
37	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
38	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
39	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
40	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
41	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
42	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
43	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
44	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
45	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
46	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
47	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
48	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
49	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
50	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
51	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
52	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
53	Pepping J "Echinacea." Am J Health Syst Pharm 56 (1999): 121-2

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