Details of Drug

Drug General Information (ID: D0802)
Drug Name	Infliximab
Drug Type	Monoclonal antibody
Drug Synonymous	Remicade (TN) Click to Show/Hide
Disease Class	EA90: Psoriasis; FA20: Rheumatoid arthritis; CA23: Asthma
Therapeutic Class	Immunosuppressive Agents
External Link
	TTD ID	D0PG5G
	VARIDT ID	DR00451

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM016 Altered formation of CYP450 enzymes BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Infliximab
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[42], [9], [45]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[42], [9], [45]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[42], [9], [45]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[42], [9], [45]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[42], [9], [45]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[42], [9], [45]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[42], [9], [45]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[42], [9], [45]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[7], [41], [38], [8], [42], [43], [9], [44], [30], [4], [5], [45], [46], [47], [48]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 208
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0085		Anakinra	C20H23N5O7S2	146171046	Major		Inter Info	[7], [8], [1], [9], [10], [5]
D0114		Asparaginase Escherichia coli	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0442		Denileukin diftitox	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0717		Gemtuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [5], [6]
D0004		Abatacept	NA	NA	Major		Inter Info	[11], [5]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0027		Aflibercept	NA	NA	Major		Inter Info	[1], [5], [6]
D0048		Altretamine	C9H18N6	2123	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Major		Inter Info	[1], [5], [6]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Major		Inter Info	[1], [5], [6]
D0118		Atezolizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0134		Azacitidine	C8H12N4O5	9444	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0136		Azathioprine	C9H7N7O2S	2265	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[12], [7], [13]
D0147		Basiliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0150		Belantamab mafodotin	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0151		Belatacept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0152		Belimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0153		Belinostat	C15H14N2O4S	6918638	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0172		Betamethasone	C22H29FO5	9782	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0191		Blinatumomab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0199		Brentuximab vedotin	NA	NA	Major		Inter Info	[1], [5], [6]
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0209		Brodalumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0223		Busulfan	C6H14O6S2	2478	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0227		Cabazitaxel	C45H57NO14	9854073	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0246		Canakinumab	NA	NA	Major		Inter Info	[12], [7], [14], [8], [1], [9], [10], [5]
D0249		Capecitabine	C15H22FN3O6	60953	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0264		Carmustine	C5H9Cl2N3O2	2578	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [15]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0392		Corticotropin	C207H308N56O58S	16132265	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0404		Cytarabine	C9H13N3O5	6253	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0407		Dacarbazine	C6H10N6O	135398738	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0410		Dactinomycin	C62H86N12O16	457193	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0422		Daratumumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1], [5], [6]
D0431		Decitabine	C8H12N4O4	451668	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0499		Dimethyl fumarate	C6H8O4	637568	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0507		Diroximel fumarate	C11H13NO6	73330464	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[1], [5], [6]
D0540		Dupilumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0541		Durvalumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0560		Elotuzumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0627		Etoposide	C29H32O13	36462	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[20]
D0666		Floxuridine	C9H11FN2O5	5790	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0669		Fludarabine	C10H12FN5O4	657237	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0671		Fludrocortisone	C21H29FO5	31378	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0675		Fluorouracil	C4H3FN2O2	3385	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0710		Ganciclovir	C9H13N5O4	135398740	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0714		Gemcitabine	C9H11F2N3O4	60750	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0747		Guselkumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0773		Hydrocortisone	C21H30O5	5754	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0780		Hydroxyurea	CH4N2O2	3657	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[1], [5], [6]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0801		Inebilizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[1], [5], [6]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[1], [5], [6]
D0851		Isatuximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0873		Ixabepilone	C27H42N2O5S	6445540	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0875		Ixekizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[7], [21]
D0910		Levamisole	C11H12N2S	26879	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0939		Lisocabtagene maraleucel	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0945		Lomustine	C9H16ClN3O2	3950	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0986		Mechlorethamine	C5H11Cl2N	4033	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0996		Melphalan	C13H18Cl2N2O2	460612	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1007		Mercaptopurine	C5H4N4S	667490	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1077		Mitomycin	C15H18N4O5	5746	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1079		Mitoxantrone	C22H28N4O6	4212	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1083		Mogamulizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1085		Monomethyl fumarate	C5H6O4	5369209	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1093		Muromonab	NA	NA	Major		Inter Info	[1], [5], [6]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[27]
D1113		Naxitamab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1118		Nelarabine	C11H15N5O5	3011155	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1140		Niraparib	C19H20N4O	24958200	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1161		Obinutuzumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1162		Ocrelizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1164		Ofatumumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1168		Olaratumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[1], [5], [6]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [28]
D1212		Paclitaxel	C47H51NO14	36314	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Major		Inter Info	[1], [5], [6]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1241		Pemetrexed	C20H21N5O6	135410875	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1250		Pentostatin	C11H16N4O4	439693	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1323		Pralatrexate	C23H23N7O5	148121	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1332		Prednisolone	C21H28O5	5755	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1334		Prednisone	C21H26O5	5865	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1403		Rilonacept	NA	NA	Major		Inter Info	[12], [7], [14], [8], [1], [9], [10], [5]
D1410		Risankizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1416		Rituximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1447		Sarilumab	NA	NA	Major		Inter Info	[30], [4], [5]
D1448		Satralizumab	NA	NA	Major		Inter Info	[30], [4], [5]
D1454		Secukinumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1458		Selinexor	C17H11F6N7O	71481097	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1467		Siltuximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1529		Tafasitamab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1532		Talazoparib	C19H14F2N6O	135565082	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1548		Temozolomide	C6H6N6O2	5394	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1551		Teniposide	C32H32O13S	452548	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[21], [34]
D1563		Tetracosactide	C136H210N40O31S	16133802	Major		Inter Info	[1], [5], [6]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1575		Thiotepa	C6H12N3PS	5453	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1583		Tildrakizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1589		Tioguanine	C5H5N5S	2723601	Major		Inter Info	[1], [5], [6]
D1594		Tisagenlecleucel	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1599		Tocilizumab	NA	NA	Major		Inter Info	[30], [4], [5]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[35]
D1610		Topotecan	C23H23N3O5	60700	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[1], [5], [6]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1621		Trastuzumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1622		Trastuzumab deruxtecan	NA	NA	Major		Inter Info	[1], [5], [6]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Major		Inter Info	[1], [5], [6]
D1639		Trifluridine	C10H11F3N2O5	6256	Major		Inter Info	[1], [5], [6]
D1646		Trimetrexate	C19H23N5O3	5583	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[7], [36]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1671		Ustekinumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1676		Valganciclovir	C14H22N6O5	135413535	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1685		Vedolizumab	NA	NA	Major		Inter Info	[1], [2], [37], [3], [4], [5], [6]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[1], [5], [6]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1234		Pegaspargase	C14H19NO	436058	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[31], [38], [39]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[40]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[73]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[74]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [92]
	Additive myelosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [16], [17]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[12], [18], [19]
	Increased risk of hepatotoxicity					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[22]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[26]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[29]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[51], [52], [53], [12], [7], [54], [55], [56], [57], [58], [59], [60], [61]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[65]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[51], [52], [53], [12], [7], [54], [55], [56], [57], [58], [59], [60], [61]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[7], [72]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[75], [76]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[77], [78], [79], [80]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[81]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[77], [78], [79], [80]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[12], [7], [89], [90], [91]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[77], [78], [79], [80]
	Increased risk of peripheral neuropathy					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[62], [63], [64]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[62], [63], [64]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[62], [63], [64]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[62], [63], [64]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[62], [63], [64]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[62], [63], [64]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[62], [63], [64]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[62], [63], [64]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[62], [63], [64]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[62], [63], [64]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[62], [63], [64]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[62], [63], [64]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[62], [63], [64]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[62], [63], [64]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[62], [63], [64]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[62], [63], [64]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[62], [63], [64]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[62], [63], [64]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[62], [63], [64]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[62], [63], [64]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[62], [63], [64]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[62], [63], [64]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[62], [63], [64]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[62], [63], [64]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[62], [63], [64]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[62], [63], [64]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[62], [63], [64]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[62], [63], [64]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[62], [63], [64]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[62], [63], [64]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[62], [63], [64]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[62], [63], [64]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[93], [94]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[62], [63], [64]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[62], [63], [64]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[62], [63], [64]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[23], [24], [25]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[23], [24], [25]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[23], [24], [25]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[23], [24], [25]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[31], [12], [32]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[33]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[23], [24], [25]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[23], [24], [25]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[23], [24], [25]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[31], [49], [50]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [49], [50]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[31], [49], [50]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[31], [49], [50]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[31], [49], [50]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[31], [49], [50]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [49], [50]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[31], [49], [50]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[82], [31], [12], [83], [84], [85], [49], [86], [87], [88], [50]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[31], [49], [50]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[31], [49], [50]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[31], [49], [50]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[95]
	Antagonize the effect of probiotics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[66], [67], [68]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[69], [70], [71]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[69], [70], [71]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[69], [70], [71]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[69], [70], [71]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[96], [97], [98]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[96], [97], [98]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[96], [97], [98]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[96], [97], [98]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[96], [97], [98]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[96], [97], [98]

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