Drug General Information (ID: DDIR79GAPY)
Drug Name			Infliximab		Drug Info		Tocilizumab		Drug Info
Drug Type		Monoclonal antibody				Monoclonal antibody
Therapeutic Class		Immunosuppressive Agents				Interleukin Inhibitors

Mechanism of Infliximab-Tocilizumab Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Infliximab				Tocilizumab
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Infliximab and Tocilizumab

Recommended Action
Management		Concomitant use of IL-6 inhibitors with other biologic DMARDs should be avoided.

References
1	Product Information. Kevzara (sarilumab). sanofi-aventis, Bridgewater, NJ.
2	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
3	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.