Drug General Information (ID: DDID8402KJ)
Drug Name			Calcium carbonate		Drug Info		Bisacodyl		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antacids/Minerals And Electrolytes				Laxatives
Structure

Mechanism of Calcium carbonate-Bisacodyl Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Calcium carbonate				Bisacodyl
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Bisacodyl due to altered gastric pH caused by Calcium carbonate

Recommended Action
Management		The administration of antacids and bisacodyl should be separated by at least one hour.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".