Details of Drug

Details of Drug

 Drug General Information (ID: D0184)
  Drug Name
Bisacodyl
  Drug Type Small molecule
  Drug Synonymous
bisacodyl; 603-50-9; Dulcolax; Bicol; Durolax; Brocalax; Stadalax; Sanvacual; Hillcolax; Fenilaxan; Endokolat; Theralax; Dulcolan; Nigalax; Laxorex; Laxadin; Neolax; Laxine; Ivilax; Eulaxan; Ulcolax; Telemin; Laxans; Godalax; Zetrax; Pyrilax; Sk-bisacodyl; Laxanin N; Bisacodylum; Bisacodilo; Deficol; LACO; LA96a; Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester); HalfLytely; Bisacodylum [INN-Latin]; Bisacodilo [INN-Spanish]; (Pyridin-2-ylmethylene)bis(4,1-phenylene) diacetate; Bis(p-acetoxyphenyl)-2-pyridylmethane
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  Disease Class DD91: Irritable bowel syndrome
  Therapeutic Class Laxatives
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C22H19NO4
  InChI 1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3
  InChIKey KHOITXIGCFIULA-UHFFFAOYSA-N
  Canonical SMILES CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3
  External Link
Pubchem ID 2391
CAS Number 603-50-9
CHEBI ID 3125
TTD ID D07IEF
INTEDE ID DR2267

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM006  Pharmacodynamic additive effects
BM003  Complex formation
BM005  Altered gastric pH
BM014  Interference of cell/tissue uptake
BM054  Increased risk of GI mucosal injury/bleeding risk
BM065  Increased risk of hypokalemia
BM081  Increased risk of ventricular arrhythmias
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Bisacodyl
      Affected gastrointestinal absorption
   Complex formation Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Moderate    Inter Info   
[3], [9]
   Altered gastric pH Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[3]
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Moderate    Inter Info   
[3]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[3]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[3]
D1480
 
Sodium bicarbonate
 
CHNaO3
 
516892 
Moderate    Inter Info   
[3]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0670
 
Fludeoxyglucose (18F)
 
C6H11FO5
 
170049 
Moderate    Inter Info   
[2], [9], [10]
      Pharmacodynamic additive effects
   Increased risk of GI mucosal injury/bleeding risk Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[11], [12], [13]
D1309
 
Polyethylene glycol (3350)
 
C2H6O2
 
174 
Moderate    Inter Info   
[11], [12], [13]
   Increased risk of hypokalemia Drug Num:  12
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0172
 
Betamethasone
 
C22H29FO5
 
9782 
Moderate    Inter Info   
[4], [5], [7]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Moderate    Inter Info   
[4], [5], [7]
D0392
 
Corticotropin
 
C207H308N56O58S
 
16132265 
Moderate    Inter Info   
[4], [5], [7]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[4], [5], [7]
D0671
 
Fludrocortisone
 
C21H29FO5
 
31378 
Moderate    Inter Info   
[4], [5], [7]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Moderate    Inter Info   
[4], [5], [7]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Moderate    Inter Info   
[4], [5], [7]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Moderate    Inter Info   
[4], [5], [7]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Moderate    Inter Info   
[4], [5], [7]
D1563
 
Tetracosactide
 
C136H210N40O31S
 
16133802 
Moderate    Inter Info   
[4], [5], [7]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[4], [5], [7]
D1630
 
Triamcinolone (ophthalmic)
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[4], [5], [7]
   Increased risk of ventricular arrhythmias Drug Num:  148
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0003
 
Abarelix
 
C72H95ClN14O14
 
16131215 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[2], [3], [6]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0107
 
Arsenic trioxide
 
As2O3
 
14888 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0700
 
Fostemsavir
 
C25H26N7O8P
 
11319217 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1388
 
Relugolix
 
C29H27F2N7O5S
 
10348973 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1634
 
Triclabendazole
 
C14H9Cl3N2OS
 
50248 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0342
 
Cisapride
 
C23H29ClFN3O4
 
6917698 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0358
 
Clofazimine
 
C27H22Cl2N4
 
2794 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0437
 
Degarelix
 
C82H103ClN18O16
 
16136245 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Moderate    Inter Info   
[2], [3], [6]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0514
 
Dolasetron
 
C19H20N2O3
 
3033818 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0632
 
Ezogabine
 
C16H18FN3O2
 
121892 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0737
 
Goserelin
 
C59H84N18O14
 
5311128 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0738
 
Granisetron
 
C18H24N4O
 
5284566 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0749
 
Halofantrine
 
C26H30Cl2F3NO
 
37393 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0758
 
Histrelin
 
C66H86N18O12
 
25077993 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0779
 
Hydroxychloroquine
 
C18H26ClN3O
 
3652 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0806
 
Inotuzumab ozogamicin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0908
 
Leuprolide
 
C59H84N16O12
 
657181 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Moderate    Inter Info   
[2], [3], [6]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D0948
 
Lopinavir
 
C37H48N4O5
 
92727 
Moderate    Inter Info   
[2], [3], [6]
D0960
 
Lumefantrine
 
C30H32Cl3NO
 
6437380 
Moderate    Inter Info   
[2], [3], [6]
D0992
 
Mefloquine
 
C17H16F6N2O
 
4046 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1137
 
Nilutamide
 
C12H10F3N3O4
 
4493 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1181
 
Ondansetron
 
C18H19N3O
 
4595 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1210
 
Oxytocin
 
C43H66N12O12S2
 
439302 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1216
 
Palonosetron
 
C19H24N2O
 
6337614 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1254
 
Perflutren
 
C3F8
 
6432 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1290
 
Pimavanserin
 
C25H34FN3O2
 
10071196 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1339
 
Primaquine
 
C15H21N3O
 
4908 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1342
 
Probucol
 
C31H48O2S2
 
4912 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1356
 
Propofol
 
C12H18O
 
4943 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1424
 
Romidepsin
 
C24H36N4O6S2
 
5352062 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[2], [3], [6]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1463
 
Sevoflurane
 
C4H3F7O
 
5206 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1522
 
Sunitinib
 
C22H27FN4O2
 
5329102 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1555
 
Terfenadine
 
C32H41NO2
 
5405 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1651
 
Triptorelin
 
C64H82N18O13
 
25074470 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[1], [2], [3], [4], [5], [6]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  25
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0012
 
Acetazolamide
 
C4H6N4O3S2
 
1986 
Moderate    Inter Info   
[5], [7], [8]
D0058
 
Amiloride
 
C6H8ClN7O
 
16231 
Moderate    Inter Info   
[5], [7], [8]
D0158
 
Bendroflumethiazide
 
C15H14F3N3O4S2
 
2315 
Moderate    Inter Info   
[5], [7], [8]
D0166
 
Benzthiazide
 
C15H14ClN3O4S3
 
2343 
Moderate    Inter Info   
[5], [7], [8]
D0217
 
Bumetanide
 
C17H20N2O5S
 
2471 
Moderate    Inter Info   
[5], [7], [8]
D0321
 
Chlorothiazide
 
C7H6ClN3O4S2
 
2720 
Moderate    Inter Info   
[5], [7], [8]
D0326
 
Chlorthalidone
 
C14H11ClN2O4S
 
2732 
Moderate    Inter Info   
[5], [7], [8]
D0479
 
Diclofenamide
 
C6H6Cl2N2O4S2
 
3038 
Moderate    Inter Info   
[5], [7], [8]
D0613
 
Etacrynic acid
 
C13H12Cl2O4
 
3278 
Moderate    Inter Info   
[5], [7], [8]
D0704
 
Furosemide
 
C12H11ClN2O5S
 
3440 
Moderate    Inter Info   
[5], [7], [8]
D0771
 
Hydrochlorothiazide
 
C7H8ClN3O4S2
 
3639 
Moderate    Inter Info   
[5], [7], [8]
D0775
 
Hydroflumethiazide
 
C8H8F3N3O4S2
 
3647 
Moderate    Inter Info   
[5], [7], [8]
D0798
 
Indapamide
 
C16H16ClN3O3S
 
3702 
Moderate    Inter Info   
[5], [7], [8]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[14]
D0846
 
Irinotecan (liposomal)
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[14]
D0978
 
Mannitol
 
C6H14O6
 
6251 
Moderate    Inter Info   
[5], [7], [8]
D1018
 
Methazolamide
 
C5H8N4O3S2
 
4100 
Moderate    Inter Info   
[5], [7], [8]
D1048
 
Metolazone
 
C16H16ClN3O3S
 
4170 
Moderate    Inter Info   
[5], [7], [8]
D1311
 
Polythiazide
 
C11H13ClF3N3O4S3
 
4870 
Moderate    Inter Info   
[5], [7], [8]
D1501
 
Spironolactone
 
C24H32O4S
 
5833 
Moderate    Inter Info   
[5], [7], [8]
D1611
 
Torasemide
 
C16H20N4O3S
 
41781 
Moderate    Inter Info   
[5], [7], [8]
D1631
 
Triamterene
 
C12H11N7
 
5546 
Moderate    Inter Info   
[5], [7], [8]
D1633
 
Trichlormethiazide
 
C8H8Cl3N3O4S2
 
5560 
Moderate    Inter Info   
[5], [7], [8]
D1668
 
Urea
 
CH4N2O
 
1176 
Moderate    Inter Info   
[5], [7], [8]
D0929
 
Linaclotide
 
C59H79N15O21S6
 
16158208 
Minor    Inter Info   
[15], [16]
References
1 Canadian Pharmacists Association.
2 Cerner Multum, Inc. "Australian Product Information.".
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
5 Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
6 Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
7 Leach MJ, Page AT. Herbal medicine for insomnia: A systematic review and meta-analysis. Sleep Med Rev. 2015 Dec;24:1-12.
8 Atsmon J, Dolev E "Drug-induced hypomagnesaemia : scope and management." Drug Saf 28 (2005): 763-88
9 Multum Information Services, Inc. Expert Review Panel.
10 Product Information. Metamucil (psyllium). Procter and Gamble Pharmaceutic, Cincinnati, OH.
11 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
12 Product Information. MoviPrep (polyethylene glycol 3350 with electrolytes). Physicians Total Care, Tulsa, OK.
13 Soh JS, Kim KJ. Combination could be another tool for bowel preparation? World J Gastroenterol. 2016 Mar 14;22(10):2915-21. doi: 10.3748/wjg.v22.i10.2915.
14 Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
15 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
16 Product Information. Linzess (linaclotide). Forest Pharmaceuticals, St. Louis, MO.